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Table 4 Effect of methanol extract of P. foetida on Pylorus-ligated rats

From: Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India

Treatment

Mean ulcer Index (SEM)

% Protection

Volume (ml) of gastric secretion

Free Acidity (Eq/l/100gm)

Total Acidity (Eq/l/100gm)

pH

Group 1 Normal Control (Distl. Water, 5 ml/kg, p.o.)

0.33 ± 0.11

-

1.52 ± 0.49

71.97 ± 1.04

83.23 ± 0.68

3.65 ± 0.11

Group 2 Ulcer Control (Distl. Water, 5 ml/kg, p.o.)

7.00 ± 0.63***c

-

7.40 ± 0.61***c

88.17 ± 2.14***c

130.17 ± 6.41***c

2.38 ± 0.19***c

Group 3 Methanol extract (150 mg/kg, p.o.)

1.11 ± 0.46***

84

2.20 ± 0.35***

50.17 ± 5.12***

60.33 ± 3.20***

5.42 ± 5.50***

Group 4 Cimetidine (8 mg/kg, p. o.)

1.00 ± 0.23***

85

1.88 ± 0.22 ***

36.00 ± 5.29***

44.00 ± 1.13***

7.42 ± 0.15 ***

  1. Data were expressed as mean ± Standard Error Mean (SEM), where n=6 in each group. Differences were considered significant at ***P<0.001 when compared control group vs ulcer control group (c) and Test groups vs ulcer control group. For numerical results, one-way analysis of variance (ANOVA) with Tukey-Kramer Multiple Comparison post tests were performed using GraphPad InStat Version 3 (GraphPad Software)