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Table 1 Effect of methanol extract on gastric secretion volume, pH, acid-output and ulcer index against indomethacin-pylorus ligation induced ulcer in rats

From: Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India

Treatment

Gastric secretion (Mean ± SEM)

Ulcer index (mm) Mean ± SEM

% of ulcer protection

Volume (ml)

pH

Acid output (Eq/100 g/4 h)

Group 1 (5 ml distilled water/kg)

2.114±0.13

2.80±0.01

2.80±0.01

2.850±0.07

-

Group 2 Indomethacin (25 mg/kg)

9.280±0.09ααα

1.07±0.01ααα

24.47±2.28ααα

39.12±0.81ααα

-

Group3 MeOH PF (100 mg/kg)

4.296±0.11***

2.51±0.02***

10.99±0.11***

10.57±0.15***

72.98

Group 4 MeOH PF (200 mg/kg)

2.670±0.21***

2.71±0.71***

7.62±0.14***

8.38±0.05***

78.58

Group5 Ranitidine (10 mg/kg)

2.426±0.52***

2.89±0.03***

5.30±0.31***

6.69±0.06***

82.89

  1. MeOH PF= methanol extract of Paederia foetida; n=5; Data = Mean±SEM; αααP<0.001 (G1 Vs G2); ***P<0.001, (Group 2 Vs Group 3, 4 & 5)