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Table 3 Effect of the methanolic fraction from Clerodendrum umbellatum leaves aqueous extract on some parameters of the liver function of mice on the 65th day post-infection

From: Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice

Groups NIC IC PZQ CuF100 CuF200 CuF400
Number of animals (n) 5 6 6 6 6 6
ALT (U/mL) 266.28 ± 9.90 746.07 ± 59.86 391.66 ± 31.85 408.49 ± 36.27 420.52 ± 26.68 481.76 ± 47.09
p <0.001 <0.001 <0.001 <0.001 <0.001
% change +180.18 −47.50 −45.25 −43.63 −35.43
AST (U/m) 167.84 ± 10.55 234.23 ± 14.58 168.13 ± 13.41 234.52 ± 23.74 248.24 ± 20.11 261.75 ± 16.25
p n.s n.s n.s n.s n.s
% change +39.55 −28.22 +0.12 +5.98 +11.75
ALP (U/L) 19.02 ± 2.87 8.04 ± 2.88 20.68 ± 3.24 13.10 ± 2.90 18.38 ± 2.86 20.33 ± 4.07
p n.s n.s n.s n.s n.s
% change −57.73 +157.21 +62.93 +128.61 +152.86
Total proteins (mg/mL) 4.43 ± 0.22 3.17 ± 0.29 4.73 ± 0.15 4.88 ± 0.18 5.39 ± 0.18 4.59 ± 0.16
p <0.001 <0.001 <0.001 <0.001 <0.001
% change −28.44 +49.21 +53.94 +70.03 +44.79
Total bilirubin (μmol/L) 19.34 ± 1.71 23.15 ± 1.80 15.32 ± 1.76 16.87 ± 3.78 20.84 ± 1.50 25.59 ± 3.88
p n.s n.s n.s n.s n.s
% change +19.70 −33.82 −27.13 −9.98 +10.54
  1. Data are expressed as mean ± SEM
  2. ANOVA followed by Newman-Keuls multiple comparison test was used to compare on one hand, the infected-untreated mice (IC) to the non-infected mice (NIC), and secondly the infected-treated mice (PZQ, CuF100, CuF200, CuF400) to the infected-untreated mice (IC). n.s non-significant
  3. ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase