Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice

Table 3 Effect of the methanolic fraction from Clerodendrum umbellatum leaves aqueous extract on some parameters of the liver function of mice on the 65th day post-infection

Groups	NIC	IC	PZQ	CuF100	CuF200	CuF400
Number of animals (n)	5	6	6	6	6	6
ALT (U/mL)	266.28 ± 9.90	746.07 ± 59.86	391.66 ± 31.85	408.49 ± 36.27	420.52 ± 26.68	481.76 ± 47.09
p		<0.001	<0.001	<0.001	<0.001	<0.001
% change		+180.18	−47.50	−45.25	−43.63	−35.43
AST (U/m)	167.84 ± 10.55	234.23 ± 14.58	168.13 ± 13.41	234.52 ± 23.74	248.24 ± 20.11	261.75 ± 16.25
p		n.s	n.s	n.s	n.s	n.s
% change		+39.55	−28.22	+0.12	+5.98	+11.75
ALP (U/L)	19.02 ± 2.87	8.04 ± 2.88	20.68 ± 3.24	13.10 ± 2.90	18.38 ± 2.86	20.33 ± 4.07
p		n.s	n.s	n.s	n.s	n.s
% change		−57.73	+157.21	+62.93	+128.61	+152.86
Total proteins (mg/mL)	4.43 ± 0.22	3.17 ± 0.29	4.73 ± 0.15	4.88 ± 0.18	5.39 ± 0.18	4.59 ± 0.16
p		<0.001	<0.001	<0.001	<0.001	<0.001
% change		−28.44	+49.21	+53.94	+70.03	+44.79
Total bilirubin (μmol/L)	19.34 ± 1.71	23.15 ± 1.80	15.32 ± 1.76	16.87 ± 3.78	20.84 ± 1.50	25.59 ± 3.88
p		n.s	n.s	n.s	n.s	n.s
% change		+19.70	−33.82	−27.13	−9.98	+10.54

Data are expressed as mean ± SEM
ANOVA followed by Newman-Keuls multiple comparison test was used to compare on one hand, the infected-untreated mice (IC) to the non-infected mice (NIC), and secondly the infected-treated mice (PZQ, CuF100, CuF200, CuF400) to the infected-untreated mice (IC). n.s non-significant
ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase

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