Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice

Table 2 Effect of the methanolic fraction from Clerodendrum umbellatum leaves aqueous extract on the liver and spleen weights of mice on the 65th day post-infection

Groups	Number of animals (n)	Liver			Spleen
Groups	Number of animals (n)	Weight (g/100 g)	p	% change	Weight (g/100 g)	p	% change
NIC	5	6.23 ± 0.34			0.50 ± 0.04
IC	6	9.21 ± 0.37	<0.001	+47.83	1.45 ± 0.17	<0.001	+190.00
PZQ	6	6.57 ± 0.46	<0.001	−28.66	0.43 ± 0.08	<0.001	−70.34
CuF100	6	7.68 ± 0.28	<0.05	−16.61	0.77 ± 0.08	<0.001	−46.90
CuF200	6	7.90 ± 0.48	<0.05	−14.22	0.79 ± 0.03	<0.001	−45.52
CuF400	6	5.96 ± 0.47	<0.001	−35.29	0.66 ± 0.10	<0.001	−54.48

Data are expressed as mean ± SEM
ANOVA followed by Newman-Keuls multiple comparison test was used to compare on one hand, the infected-untreated mice (IC) to the non-infected mice (NIC), and secondly the infected-treated mice (PZQ, CuF100, CuF200, CuF400) to the infected-untreated mice (IC)

ISSN: 2662-7671