Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice

Table 1 Effect of the methanolic fraction from Clerodendrum umbellatum leaves aqueous extract on the body weight of mice at pre-infection and on the 65th day post-infection

Groups	Number of animals (n)	Body weight (g)		Weight gain (%)	p
Groups	Number of animals (n)	Pre-infection (1st day)	Post-infection (65th day)	Weight gain (%)	p
NIC	5	19.30 ± 0.83	24.23 ± 1.05	29.53 ± 2.04 (24.28–34.78)
IC	6	23.51 ± 0.90	24.31 ± 0.80	3.97 ± 3.87 (−5.50–13.44)	<0.001
PZQ	6	21.22 ± 1.04	26.00 ± 0.98	22.89 ± 2.89 (15.47–30.31)	<0.001
CuF100	6	23.55 ± 0.55	28.14 ± 0.85	19.54 ± 2.56 (12.95–26.12)	<0.01
CuF200	6	21.04 ± 0.89	24.94 ± 1.03	18.60 ± 1.43 (14.93–22.26)	<0.001
CuF400	6	22.74 ± 0.51	27.07 ± 0.74	19.06 ± 1.96 (14.03–24.09)	<0.001

Data are expressed as mean ± SEM
Values in brackets represent the 95 % confidence intervals
ANOVA followed by Newman-Keuls multiple comparison test was used to compare on one hand, the infected-untreated mice (IC) to the non-infected mice (NIC), and secondly the infected-treated mice (PZQ, CuF100, CuF200, CuF400) to the infected-untreated mice (IC)

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