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Table 7 In vivo assessment of the antioxidant activity of F.hermonis EtAc extract (Ferula), Ferutinin (Ft) using catalase levels in serum of alloxan-induced diabetic mice (n = 7)

From: Acute and subchronic in-vivo effects of Ferula hermonis L. and Sambucus nigra L. and their potential active isolates in a diabetic mouse model of neuropathic pain

Group

Dose (mg/kg)

Catalase level ± S.E.M. (kU/I)

  

1st day

3rd day

5th day

8th day

Control

__

41.00 ± 1.50

41.50 ± 1.60

40.86 ± 1.20

41.62 ± 1.70

Diabetic controla

__

23.67 ± 1.60***

24.93 ± 1.30***

23.01 ± 1.90***

22.02 ± 1.40***

GBb

5

22.60 ± 1.70

25.00 ± 1.70

31.54 ± 1.40*

32.37 ± 1.00**

Ferula b

12.5

23.31 ± 1.40

22.48 ± 3.10

23.00 ± 2.50*

23.80 ± 1.60**

Ferula b

25

23.17 ± 1.70

21.05 ± 2.10

23.20 ± 2.30*

23.90 ± 1.30**

Ferula b

50

23.02 ± 1.60

23.17 ± 2.10

24.30 ± 2.60*

25.20 ± 1.30*

Ftb

0.4

20.10 ± 1.20

19.70 ± 1.10

21.00 ± 1.60*

22.10 ± 1.20*

Ftb

0.8

21.05 ± 1.50

21.58 ± 1.60

23.35 ± 1.80*

23.80 ± 0.80*

Ftb

1.6

22.50 ± 1.80

22.80 ± 1.40

23.91 ± 1.10*

25.62 ± 1.20*

  1. S.E.M. standard error of the mean
  2. *p < 0.05 significant from the control animals
  3. **p < 0.01 significant from the control animals
  4. ***p < 0.001 significant from the control animals
  5. aCompared to vehicle control
  6. bCompared to diabetic control