Fig. 3

Effect of F.hermonis EtAc extract (Ferula), Ferutinin (Ft), S.nigra aqueous extract (Elder), Kaempferol (KMF) and Tramadol (TRA) 10 mg/kg, as a positive control, on tactile allodynia in neuropathic model in alloxan-induced diabetic mice a Ferula group: paw withdrawal thresholds to von Frey filaments were determined on hind paw prior to (Predose) and up to 8 weeks following i.p. injection of (12.5, 25 and 50 mg/Kg) Ferula b Ft group: paw withdrawal thresholds to von Frey filaments were determined on hind paw prior to (Predose) and up to 8 weeks following i.p. injection of (0.4, 0.8 and 1.6 mg/Kg) Ft. c Elder group: paw withdrawal thresholds to von Frey filaments were determined on hind paw prior to (Predose) and up to 8 weeks following i.p. injection of (50, 100 and 200 mg/Kg) Elder. d KMF group: paw withdrawal thresholds to von Frey filaments were determined on hind paw prior to (Predose) and up to 8 weeks following I.P. injection of (16, 32 and 64 mg/Kg) KMF. (NORM)normal non-diabetic untreated mice. *P ≤0.05 and **P ≤0.01 compared to vehicle (VEH) (n = 7 animals/group)