Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress

Table 1 Changes in body weight and behavioral test

Groups	Body weight (g)	% Sucrose preference	OFT		Immobility time ( s )
			Number of crossing	Number of rearing
con	357.50 ± 10.00	88.06 ± 3.24	36.71 ± 3.55	15.25 ± 2.15	62.09 ± 6.52
con + FO	361.25 ± 11.29	79.24 ± 3.87	33.21 ± 3.66	15.31 ± 2.52	56.02 + 10.28
con + ser	351.11 ± 14.28	85.42 ± 3.65	40.41 ± 3.29	14.67 ± 1.70	39.00 ± 7.64
CUMS	319.44 ± 11.74**	46.79 ± 3.35**	11.25 ± 4.46**	8.17 ± 2.22*	101.52 ± 11.43*
CUMS + FO	301.88 ± 7.32	77.01 ± 3.60^##	35.91 ± 4.02^##	12.64 ± 2.47	47.33 ± 9.87^##
CUMS + ser	318.13 ± 8.76	72.46 ± 4.38^##	37.92 ± 4.75^##	15.63 ± 1.80^#	55.92 ± 7.21^##

Data are expressed as means ± SEM (n = 8)
CUMS chronic unpredictable mild stress, con control, FO fish oil, ser sertraline
*P < 0.05, **P < 0.01 compared to control group. ^#P < 0.05, ^##P < 0.01 compared to CUMS group

ISSN: 2662-7671