Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress

Table 4 Effect of turmeric on the serum levels of ALT, AST, ALP, Bilirubin, ALB and TP

Groups	ALT	AST	ALP	Bilirubin	ALB	TP
Groups	(U/L)	(U/L)	(IU/L)	(mg/dl)	(g/dl)	(g/dl)
Control	36.53 ± 2.1	51 ± 2.57	186.59 ± 8.68	0.81 ± 0.04	3.67 ± 0.28	6.65 ± 0.55
TUR (100mgkg⁻¹)	34.43 ± 0.18	50.59 ± 2.3	188.43 ± 8.54	0.83 ± 0.06	3.44 ± 0.42	6.82 ± 0.59
TUR (200mgkg⁻¹)	33.9 ± 0.45	49.26 ± 0.36	184.99 ± 8.62	0.85 ± 0.05	3.42 ± 0.54	7.05 ± 0.69
MTX (20mgkg⁻¹)	49.91 ± 2.11^a	74.83 ± 3.89^a	276.61 ± 10.56^a	1.46 ± 0.1^a	2.36 ± 0.37^a	4.28 ± 0.41^a
TUR (100mgkg⁻¹) + MTX	42.42 ± 1.32^a	63.48 ± 0.25^a	226.78 ± 9.25^a	1.21 ± 0.08^a	2.9 ± 0.2^a	5.48 ± 0.46^a
TUR (200mgkg⁻¹) + MTX	39.07 ± 0.4^b	57.83 ± 0.31^b	209.42 ± 8.7^b	0.88 ± 0.07^b	3.48 ± 0.38^b	6.15 ± 0.57^b

Values are shown as mean ± S.D.
TUR Turmeric, MTX Methotrexate, ALT Alanine Aminotransferase, AST Aspartate aminotransferase, ALP Alkaline phosphatase, ALB Albumin, TP Total protein. ^aSignificant different with control group at P < 0.05. ^bSignificant different with MTX at P < 0.05

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