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Table 3 Genotypic distribution between high and low Yu-Zhi score, and adjusted odds ratios of SNPs associated with high Yu-Zhi Score in type 2 diabetes

From: Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine

 

Gene

dbSNP ID

Risk allele

Genotype#

High YZ score (%)

Low YZ score (%)

OR (95 % CI) ‡

Chr.

Unknown

rs12036718

T

CC

70.3

78.9

1.00(Ref)

1p

   

TT + CT

29.7

21.1

1.68 (0.87-3.24)

 

Unknown

rs1932064

T

CC + CT

43.2

57.9

1.00(Ref)

1p

   

TT

56.8

42.1

1.78 (1.01-3.13)*

 

Unknown

rs8179355

C

AA + AC

38.0

52.6

1.00(Ref)

1p

   

CC

62.0

47.4

1.78 (1.36-2.31)*

 

Unknown

rs9633289

T

AA + AT

40.7

54.9

1.00(Ref)

1p

   

TT

59.3

45.1

1.73 (1.13-2.63)*

 

Unknown

rs7565310

A

GG + AG

75.1

86.5

1.00(Ref)

2q

   

AA

24.9

13.5

2.11 (1.49-2.99)*

 

PCDH10

rs7694118

C

TT

4.1

13.3

1.00(Ref)

4q

   

CC + CT

95.9

86.7

0.27 (0.10-0.72) *

 

Unknown

rs164368

T

CC

6.7

2.2

1.00(Ref)

5q

   

TT + CT

93.3

97.8

0.30 (0.14-0.64)*

 

PON2

rs7493

C

GG + CG

94.2

99.3

1.00(Ref)

7q

   

CC

5.8

0.7

8.62 (2.60-28.52)*

 

PON2

rs2299263

A

GG + AG

94.2

99.3

1.00(Ref)

7q

   

AA

5.8

0.7

8.62 (2.60-28.52)*

 

PON2

rs17166875

T

CC + CT

94.2

99.3

1.00(Ref)

7q

   

TT

5.8

0.7

8.62 (2.60-28.52)*

 

FREM2

rs12865228

G

TT

29.2

38.7

1.00(Ref)

13q

   

GG + GT

70.8

61.3

1.59 (1.21-2.10)*

 

FREM2

rs4526895

C

TT

29.2

38.7

1.00(Ref)

13q

   

CC + CT

70.8

61.3

1.59 (1.21-2.10)*

 

Unknown

rs17118382

A

GG

4.0

8.8

1.00(Ref)

14q

   

AA + AG

96.0

91.2

0.42 (0.19-0.95)*

 

Unknown

rs194045

G

AA + AG

10.6

21.3

1.00(Ref)

16p

   

GG

89.4

78.7

2.20 (1.52-3.19)*

 

PIEZO2

rs8093481

A

GG + AG

39.6

58.9

1.00(Ref)

18p

   

AA

60.4

41.1

2.33 (1.31-4.12)*

 

PIEZO2

rs11660953

T

CC + CT

39.6

58.9

1.00(Ref)

18p

   

TT

60.4

41.1

2.33 (1.31-4.12)*

 

ZNF665

rs1133146

A

GG + AG

48.6

64.2

1.00(Ref)

19q

   

AA

51.4

35.8

1.94 (1.10-3.42)*

 

ZNF665

rs12971799

C

TT + CT

48.6

64.2

1.00(Ref)

19q

   

CC

51.4

35.8

1.94 (1.10-3.42)*

 

ZNF665

rs4801958

T

CC + CT

50.1

63.2

1.00(Ref)

19q

   

TT

49.9

36.8

1.67 (1.28-2.18)*

 

ZNF665

rs12460170

G

AA + AG

50.2

63.0

1.00(Ref)

19q

   

GG

49.8

37.0

1.65 (1.26-2.15)*

 

ZNF665

rs4803055

C

TT + CT

41.4

60.6

1.00(Ref)

19q

   

CC

58.6

39.4

2.25 (1.27-3.97)*

 

Unknown

rs871913

A

GG

84.5

91.6

1.00(Ref)

20p

   

AA + AG

15.5

8.4

2.18 (0.88-5.40)

  1. Case number: High Yu-Zhi score = 538, Low Yu-Zhi score = 409
  2. Chr, chromosome; dbSNP ID, SNP database indentification; YZ, Yu-Zhi; CI, confidence intervals of odds ratio; PCDH10, protocadherin 10; PON2, paraoxonase 2; FREM2, FRAS1 related extracellular matrix protein 2; PIEZO2, piezo-type mechanosensitive ion channel component 2; ZNF665, zinc finger protein 665
  3. #Better of dominant or recessive model
  4. ‡Adjusted by age, sex, DM duration and hemoglobin A1c
  5. *Significant difference of genotype distribution between high YZ group and low YZ group (p < 0.05)