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Table 3 Genotypic distribution between high and low Yu-Zhi score, and adjusted odds ratios of SNPs associated with high Yu-Zhi Score in type 2 diabetes

From: Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine

  Gene dbSNP ID Risk allele Genotype# High YZ score (%) Low YZ score (%) OR (95 % CI)
Chr. Unknown rs12036718 T CC 70.3 78.9 1.00(Ref)
1p     TT + CT 29.7 21.1 1.68 (0.87-3.24)
  Unknown rs1932064 T CC + CT 43.2 57.9 1.00(Ref)
1p     TT 56.8 42.1 1.78 (1.01-3.13)*
  Unknown rs8179355 C AA + AC 38.0 52.6 1.00(Ref)
1p     CC 62.0 47.4 1.78 (1.36-2.31)*
  Unknown rs9633289 T AA + AT 40.7 54.9 1.00(Ref)
1p     TT 59.3 45.1 1.73 (1.13-2.63)*
  Unknown rs7565310 A GG + AG 75.1 86.5 1.00(Ref)
2q     AA 24.9 13.5 2.11 (1.49-2.99)*
  PCDH10 rs7694118 C TT 4.1 13.3 1.00(Ref)
4q     CC + CT 95.9 86.7 0.27 (0.10-0.72) *
  Unknown rs164368 T CC 6.7 2.2 1.00(Ref)
5q     TT + CT 93.3 97.8 0.30 (0.14-0.64)*
  PON2 rs7493 C GG + CG 94.2 99.3 1.00(Ref)
7q     CC 5.8 0.7 8.62 (2.60-28.52)*
  PON2 rs2299263 A GG + AG 94.2 99.3 1.00(Ref)
7q     AA 5.8 0.7 8.62 (2.60-28.52)*
  PON2 rs17166875 T CC + CT 94.2 99.3 1.00(Ref)
7q     TT 5.8 0.7 8.62 (2.60-28.52)*
  FREM2 rs12865228 G TT 29.2 38.7 1.00(Ref)
13q     GG + GT 70.8 61.3 1.59 (1.21-2.10)*
  FREM2 rs4526895 C TT 29.2 38.7 1.00(Ref)
13q     CC + CT 70.8 61.3 1.59 (1.21-2.10)*
  Unknown rs17118382 A GG 4.0 8.8 1.00(Ref)
14q     AA + AG 96.0 91.2 0.42 (0.19-0.95)*
  Unknown rs194045 G AA + AG 10.6 21.3 1.00(Ref)
16p     GG 89.4 78.7 2.20 (1.52-3.19)*
  PIEZO2 rs8093481 A GG + AG 39.6 58.9 1.00(Ref)
18p     AA 60.4 41.1 2.33 (1.31-4.12)*
  PIEZO2 rs11660953 T CC + CT 39.6 58.9 1.00(Ref)
18p     TT 60.4 41.1 2.33 (1.31-4.12)*
  ZNF665 rs1133146 A GG + AG 48.6 64.2 1.00(Ref)
19q     AA 51.4 35.8 1.94 (1.10-3.42)*
  ZNF665 rs12971799 C TT + CT 48.6 64.2 1.00(Ref)
19q     CC 51.4 35.8 1.94 (1.10-3.42)*
  ZNF665 rs4801958 T CC + CT 50.1 63.2 1.00(Ref)
19q     TT 49.9 36.8 1.67 (1.28-2.18)*
  ZNF665 rs12460170 G AA + AG 50.2 63.0 1.00(Ref)
19q     GG 49.8 37.0 1.65 (1.26-2.15)*
  ZNF665 rs4803055 C TT + CT 41.4 60.6 1.00(Ref)
19q     CC 58.6 39.4 2.25 (1.27-3.97)*
  Unknown rs871913 A GG 84.5 91.6 1.00(Ref)
20p     AA + AG 15.5 8.4 2.18 (0.88-5.40)
  1. Case number: High Yu-Zhi score = 538, Low Yu-Zhi score = 409
  2. Chr, chromosome; dbSNP ID, SNP database indentification; YZ, Yu-Zhi; CI, confidence intervals of odds ratio; PCDH10, protocadherin 10; PON2, paraoxonase 2; FREM2, FRAS1 related extracellular matrix protein 2; PIEZO2, piezo-type mechanosensitive ion channel component 2; ZNF665, zinc finger protein 665
  3. #Better of dominant or recessive model
  4. Adjusted by age, sex, DM duration and hemoglobin A1c
  5. *Significant difference of genotype distribution between high YZ group and low YZ group (p < 0.05)