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Table 2 Summary of the SNPs associated with high Yu-Zhi score in type 2 diabetes

From: Susceptible gene of stasis-stagnation constitution from genome-wide association study related to cardiovascular disturbance and possible regulated traditional Chinese medicine

     

RA frequency

     

dbSNP ID

Chr.

Position (Mb)

Gene

RA* (NRA)

High YZ score

Low YZ score

p-value‡ (Best model)

-log (p-value)

best model

Effect size (95 % CI)

FDR

rs12036718

1p

48.3

Unknow

T(C)

0.174

0.103

8.10 × 10−6

5.09

Trend

1.68 (0.95 -2.99)

1.00

rs1932064

1p

70.8

Unknow

T(C)

0.788

0.700

6.18 × 10−6

5.21

Dominant

1.62 (1.05 -2.51)

0.97

rs8179355

1p

70.9

Unknow

C(A)

0.782

0.699

7.53 × 10−6

5.12

Recessive

1.54 (1.25 -1.89)

0.86

rs9633289

1p

70.9

Unknow

T(A)

0.217

0.298

6.18 × 10−6

5.21

Recessive

1.55 (1.11 -2.15)

0.95

rs7565310

2q

128.9

Unknow

A(G)

0.484

0.380

8.63 × 10−6

5.06

Trend

1.53 (1.27 -1.84)

0.83

rs7694118

4q

134.3

PCDH10

C(T)

0.698

0.663

6.31 × 10−6

5.20

Genotype

1.30 (0.85 -1.99)

1.00

rs164368

5q

160.6

Unknow

T(C)

0.803

0.785

6.14 × 10−6

5.21

Genotype

1.12 (0.89 -1.40)

1.00

rs7493

7q

94.9

PON2

C(G)

0.180

0.177

5.33 × 10−6

5.27

Genotype

1.06 (0.74 -1.51)

1.00

rs2299263

7q

94.9

PON2

A(G)

0.180

0.177

5.33 × 10−6

5.27

Genotype

1.06 (0.74 -1.51)

1.00

rs17166875

7q

94.9

PON2

T(C)

0.180

0.177

5.33 × 10−6

5.27

Genotype

1.02 (0.81 -1.29)

1.00

rs12865228

13q

38.2

FREM2

G(T)

0.429

0.414

3.38 × 10−6

5.47

Genotype

1.06 (0.88 -1.28)

1.00

rs4526895

13q

38.2

FREM2

C(T)

0.428

0.414

1.79 × 10−6

5.75

Genotype

1.38 (0.93 -2.04)

1.00

rs17118382

14q

82.8

Unknow

A(G)

0.815

0.730

9.75 × 10−6

5.01

Allele

1.45 (1.03 -2.04)

0.98

rs194045

16p

29.2

Unknow

G(A)

0.943

0.888

6.31 × 10−6

5.20

Trend

2.13 (1.51 -3.02)

0.83

rs8093481

18p

10.7

PIEZO2

A(G)

0.757

0.656

9.64 × 10−7

6.02

Trend

1.79 (1.16 -2.77)

0.93

rs11660953

18p

10.7

PIEZO2

T(C)

0.756

0.656

1.60 × 10−6

5.79

Trend

1.79 (1.16 -2.77)

0.93

rs1133146

19q

58.4

ZNF665

A(G)

0.990

0.956

4.77 × 10−6

5.32

Allele

1.52 (1.01 -2.29)

0.99

rs12971799

19q

58.4

ZNF665

C(T)

0.700

0.599

4.77 × 10−6

5.32

Allele

1.49 (0.99 -2.25)

1.00

rs4801958

19q

58.4

ZNF665

T(C)

0.700

0.599

4.77 × 10−6

5.32

Allele

1.56 (1.29 -1.89)

0.83

rs12460170

19q

58.4

ZNF665

G(A)

0.699

0.600

7.56 × 10−6

5.12

Allele

1.56 (1.29 -1.89)

0.83

rs4803055

19q

58.4

ZNF665

C(T)

0.737

0.639

4.87 × 10−6

5.31

Allele

1.56 (1.02 -2.38)

0.98

rs871913

20p

16.1

Unknow

A(G)

0.099

0.045

8.24 × 10−6

5.08

Trend

1.86 (0.78 -4.44)

1.00