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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

Fig. 4

Proposed mechanism of IL-6 induced thrombocyte production. Addition of UPJ may enhance IL-6 secretion by both haematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) such as SHED. IL-6 can then directly enhance HSC proliferation, maturation and differentiation, or act on the liver to stimulate higher production of TPO, the chief cytokine involved in megakaryopoiesis and thrombopoiesis. Increased synthesis of SCF by MSC may also act on TPO to further stimulate megakaryopoiesis and thrombopoiesis. [CMP: common myeloid progenitor; MK: megakaryocyte.]

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