The effect of Piper laetispicum extract (EAE-P) during chronic unpredictable mild stress based on interrelationship of inflammatory cytokines, apoptosis cytokines and neurotrophin in the hippocampus

Table 5 Comparison of food utilization rate (FUR) between Fluoxetine group and EAE-P groups

Groups	Week 1	Week 2	Week 3	Week 4
Fluoxetine	11.03 ± 3.14	14.95 ± 4.42	21.39 ± 1.47	10.45 ± 0.88
15 mg/kg	11.44 ± 1.49	27.78 ± 3.99 ★	15.13 ± 1.37 ▲▲	17.07 ± 1.16
30 mg/kg	13.91 ± 2.55	19.74 ± 1.06	12.01 ± 1.47▲▲▲	30.88 ± 0.91★★★
60 mg/kg	8.53 ± 2.29	27.36 ± 1.69★★	12.61 ± 1.00▲▲▲	16.69 ± 1.37
Groups	Week 5	Week 6	Week 7	Week8
Fluoxetine	13.02 ± 1.09	5.70 ± 1.56	−3.99 ± 0.76	−3.37 ± 0.52
15 mg/kg	16.56 ± 0.84	18.52 ± 0.83★★★	5.15 ± 0.96★★★	2.49 ± 0.89★
30 mg/kg	13.39 ± 1.19	12.64 ± 1.29	5.92 ± 1.36★★★	−0.17 ± 0.54
60 mg/kg	16.41 ± 0.56	14.53 ± 1.68 ★	9.37 ± 1.75★★★	4.71 ± 0.72★★

Results are expressed as mean ± S.E.M. (n = 7–9). Statistical analysis was performed by analysis of variance (ANOVA) followed by Bonferroni’s test. ★★★ means the result is higher than Fluoxetine group. ▲▲▲means the result is lower than Fluoxetine group. ▲ p < 0.05,★p < 0.05, ▲▲P < 0.01, ★★P < 0.01, ▲▲▲P < 0.001 and ★★★P < 0.001 compared with model

ISSN: 2662-7671