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Table 1 Histologic scores of collagen fibers, VEGF and MMP-9 in studied groups

From: Topical application of Acheflan on rat skin injury accelerates wound healing: a histopathological, immunohistochemical and biochemical study

Score (%) Group Day 0 Day 8 Day 15
Collagen fibers NC 60.3 ± 0.9 16.5 ± 1.4 59.9 ± 1.6
TC 60.3 ± 0.9 70.6 ± 1.2b, c 71.3 ± 1.6b, c
TF 60.3 ± 0.9 10.9 ± 1.6b 20.2 ± 1.4b
TAc 60.3 ± 0.9 68.9 ± 1.2b, c, d 67.7 ± 0.8b, c, d
P valuea 1.0 0.0001 0.0001
VEGF NC 1.5 ± 0.7 19.5 ± 2.1 2.6 ± 1.0
TC 1.5 ± 0.7 28.2 ± 1.5b, c 15.5 ± 1.3b, c
TF 1.5 ± 0.7 18.6 ± 0.8 12.0 ± 1.2b
TAc 1.5 ± 0.7 26.4 ± 1.8b, c, d 17.3 ± 1.1b, c, d
P valuea 1.0 0.0001 0.0001
MMP-9 NC 0.9 ± 0.8 10.2 ± 0.9 8.3 ± 1.1
TC 0.9 ± 0.8 47.8 ± 1.9b, c 10.8 ± 1.9b
TF 0.9 ± 0.8 11.9 ± 1.4b 10.9 ± 1.7b
TAc 0.9 ± 0.8 17.1 ± 0.8b, c, d 11.4 ± 0.6b
P valuea 1.0 0.0001 0.001
  1. NC is negative control, TC is treated topically with Collagenase ointment, TF is treated topically with Fibrinolysin and TAc is treated topically with phytomedicine cream Acheflan. Day zero, 8th and 15th days after injury. Values are mean ± standard deviations. aAnova test. bSignificant difference when compared to NC group (Student t test, P < 0.05). cSignificant difference when compared to TF group (Student t test, P < 0.05). dSignificant difference when compared to TC group (Student t test, P < 0.05)