Fig. 2
From: Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats
Expression of c-Fos in the NAc of rat brain after systemic injections of nicotine with PJ. Rats were pretreated with PJ (10, 25, 50, 100, 200 mg/kg) 30 min before nicotine injection (0.4 mg/kg). Expression of c-Fos in the NAc after systemic injections of saline, repeated nicotine or repeated nicotine with PJ. Representative images are displayed (a). The scale bars represent 100 μm and 200 μm. The number of c-Fos cells in the NAc (b). * Significant difference from saline-treated value (only shown for nicotine-treated) ***, P < 0.001, # Significant difference from nicotine-treated value ###, P < 0.001. a; saline, b; nicotine, c; PJ10 + nicotine, d; PJ25 + nicotine, e; PJ50 + nicotine, f; PJ100 + nicotine, g; PJ200 + nicotine