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Fig. 7 | BMC Complementary and Alternative Medicine

Fig. 7

From: Water extract of brewers’ rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers’ rice-treated rats with azoxymethane-induced colon carcinogenesis

Fig. 7

Western blotting of β-catenin, cyclin D1, and c-myc in brewers’ rice treated AOM-induced colon cancer. The protein levels of β-catenin, cyclin D1, and c-myc in normal (Group 1), AOM alone (untreated) (Group 2) compared to groups of rats treated with 10 % (Group 3), 20 % (Group 4), and 40 % (Group 5) (w/w) of brewers’ rice. a Brewers’ rice decreased protein expression of β-catenin, b brewers’ rice reduced protein expression of cyclin D1, and c brewers’ rice decreased protein expression of c-myc in a dose-dependent manner. Each value expressed as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey’s test (P < 0.05). Administration of 10, 20, and 40 % (w/w) of brewers’ rice significantly reduced β-catenin, cyclin D1, and c-myc protein expression compared to the AOM-alone group (P < 0.05). However, the protein levels of cyclin D1 and c-myc did not significantly differ between 10 % and 20 % (w/w) brewers’ rice (P > 0.05)

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