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Table 2 MIC of antibiotics in combination with extracts at sub-inhibitory concentrations against P. aeruginosa PA124

From: Antibacterial and antibiotic resistance modifying activity of the extracts from allanblackia gabonensis, combretum molle and gladiolus quartinianus against Gram-negative bacteria including multi-drug resistant phenotypes

Plant extractsa

Antibiotcsb

 

CHL

AMP

ERY

KAN

STR

TET

CIP

NFX

ATB Alone

64

-

128

128

64

16

32

128

AGR

MIC/2

64(1)

- (NA)

128(1)

16(2)

32(2)

16(1)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

16(2)

64(1)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

AGB

MIC/2

64(1)

- (NA)

128(1)

128(1)

32(2)

8(2)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

AGL

MIC/2

64(1)

- (NA)

128(1)

16(2)

64(1)

16(1)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

128(1)

128(1)

64(1)

16(1)

32(1)

128(1)

AGF

MIC/2

32(2)

- (NA)

128(1)

64(2)

32(2)

16(1)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

64(2)

32(2)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

64(2)

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

128(1)

64(2)

64(1)

16(1)

32(1)

128(1)

AGFl

MIC/2

64(1)

- (NA)

128(1)

64(2)

64(1)

8(2)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

64(2)

64(1)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

64(2)

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

128(1)

128

64(1)

16(1)

32(1)

128(1)

GQW

MIC/2

64(1)

- (NA)

128(1)

64(2)

32(2)

16(1)

32(1)

128(1)

MIC/4

64(1)

- (NA)

128(1)

64(2)

64(1)

16(1)

32(1)

128(1)

MIC/8

64(1)

- (NA)

128(1)

128

64(1)

16(1)

32(1)

128(1)

MIC/16

64(1)

- (NA)

256(0.5)

128

64(1)

16(1)

32(1)

128(1)

CML

MIC/2

32(2)

- (NA)

64(2)

64(2)

32(2)

4(4)

16(2)

16(2)

MIC/4

32(2)

- (NA)

64(2)

64(2)

32(2)

4(4)

16(2)

16(2)

MIC/8

64(1)

- (NA)

128(−)

64(2)

64(1)

8(2)

32(1)

128(1)

MIC/16

641)

- (NA)

128(−)

64(2)

64(1)

8(2)

32(1)

128(1)

  1. a: Plan extracts: (AGFl : Allanblackia gabonensis Flowers, AGF : Allanblackia gabonensis Fruits, AGL: Allanblackia gabonensis Leaves, AGB: Allanblackia gabonensis Stem barks, AGR: Allanblackia gabonensis Root barks, GQW: Gladiolus quartinianus Whole plant, CML: Combretum molle Leaves); b:Antibiotics (TET: tetracycline, KAN: kanamycin, STR: streptomycin, ERY: erythromycin, CHL: chloramphenicol, NFX: norfloxacin, CIP: ciprofloxacin, AMP: ampicillin); − : MIC not detected at up to 256 μg/mL; (): Modulation factor or gain of activity; NA: Not applicable, Values in bold represent the modulation factor ≥ 2, the selected extracts and its concentrations to be used on others MDR bacteria