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Table 2 Effect of crude aqueous, methanol and chloroform leaf extracts of O. quadripartita on PCV and BW of O. quadripartita on P. berghei-infected mice

From: Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice

Description Dose (mg/kg/day) PCV BW (g)
D0 D4 % change p-value** D0 D4 % change p-value**
Aqueous 200 60.4 ± 0.60 56.0 ± 0.89a −7.28 0.02, 0.05 31.2 ± 0.37 26.5 ± 0.76 a −15.06 0.000, 1.000
400 56.6 ± 1.28 54.0 ± 1.14 −4.59 0.17, 0.34 25.2 ± 0.37 21.8 ± 0.58 a −13.49 0.000, 0.005
600 58.6 ± 2.02 56.8 ± 1.98* −3.07 0.34, 0.01 28.6 ± 0.40 25.1 ± 0.47 a −12.23 0.000, 0.000
Methanol 200 58.4 ± 1.77 54.2 ± 1.46 a −7.19 0.02, 0.29 30.6 ± 0.40 26.4 ± 0.24 a −13.72 0.000, 1.000
400 57.0 ± 1.60 53.2 ± 1.20 a −6.67 0.04, 0.59 28.2 ± 0.37 24.6 ± 0.40 a −12.76 0.000, 0.522
600 59.4 ± 0.40 55.8 ± 0.73 −6.06 0.06, 0.06 25.6 ± 0.40 23.2 ± 0.37a −09.37 0.000, 0.112
Chloroform 200 57.2 ± 1.59 54.2 ± 1.31 −5.24 0.11, 0.29 27.6 ± 0.24 26.2 ± 0.37* −05.07 0.027, 0.000
400 56.4 ± 0.75 55.0 ± 0.54 −2.48 0.46, 0.34 28.6 ± 0.50 30.8 ± 0.58* +07.69 0.001, 0.000
600 54.8 ± 1.24 53.8 ± 1.52 −1.82 0.59, 0.17 27.0 ± 0.31 29.6 ± 0.40* +09.62 0.000, 0.000
dH2O (NC) 0.2 ml 56.8 ± 1.93 52.2 ± 1.71 a −8.09 0.017 29.0 ± 0.31 23.6 ± 0.24 a −18.62 0.000
T-80 (NC) 0.2 ml 58.0 ± 1.51 52.4 ± 0.92 a −9.65 0.004 28.8 ± 0.48 23.0 ± 0.44 a −20.13 0.000
CQ 25 56.8 ± 0.96 56.8 ± 0.89* 0.00 0.674 29.8 ± 0.48 33.2 ± 0.37*a +11.40 0.000
  1. Keys: Values for the packed cell volume (PCV) and body weight (BW) are presented as mean (M) ± standard error of the mean (SEM); n = 5 (number of mice/group in a single experiment); D0: day 0 (day-of-extract-inoculation); D4 = day 4 (the fifth day pos-extract-inoculation; mg/kg/day: 1mg of extract per one kilogram of mice for one day; NC: negative control; T-80 = Tween-80 (NC for chloroform extract); dH2O: distilled water (NC for aqueous and methanol extract); CQ: chloroquine phosphate; *: significant compared with that of NC; a: significant difference between D0 and D4. **the first value is for the comparison between D0 and D4, the second is with the NC