Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice

Table 2 Effect of crude aqueous, methanol and chloroform leaf extracts of O. quadripartita on PCV and BW of O. quadripartita on P. berghei-infected mice

Description	Dose (mg/kg/day)	PCV				BW (g)
Description	Dose (mg/kg/day)	D0	D4	% change	p-value**	D0	D4	% change	p-value**
Aqueous	200	60.4 ± 0.60	56.0 ± 0.89^a	−7.28	0.02, 0.05	31.2 ± 0.37	26.5 ± 0.76 ^a	−15.06	0.000, 1.000
	400	56.6 ± 1.28	54.0 ± 1.14	−4.59	0.17, 0.34	25.2 ± 0.37	21.8 ± 0.58 ^a	−13.49	0.000, 0.005
	600	58.6 ± 2.02	56.8 ± 1.98*	−3.07	0.34, 0.01	28.6 ± 0.40	25.1 ± 0.47 ^a	−12.23	0.000, 0.000
Methanol	200	58.4 ± 1.77	54.2 ± 1.46 ^a	−7.19	0.02, 0.29	30.6 ± 0.40	26.4 ± 0.24 ^a	−13.72	0.000, 1.000
	400	57.0 ± 1.60	53.2 ± 1.20 ^a	−6.67	0.04, 0.59	28.2 ± 0.37	24.6 ± 0.40 ^a	−12.76	0.000, 0.522
	600	59.4 ± 0.40	55.8 ± 0.73	−6.06	0.06, 0.06	25.6 ± 0.40	23.2 ± 0.37^a	−09.37	0.000, 0.112
Chloroform	200	57.2 ± 1.59	54.2 ± 1.31	−5.24	0.11, 0.29	27.6 ± 0.24	26.2 ± 0.37*	−05.07	0.027, 0.000
	400	56.4 ± 0.75	55.0 ± 0.54	−2.48	0.46, 0.34	28.6 ± 0.50	30.8 ± 0.58*	+07.69	0.001, 0.000
	600	54.8 ± 1.24	53.8 ± 1.52	−1.82	0.59, 0.17	27.0 ± 0.31	29.6 ± 0.40*	+09.62	0.000, 0.000
dH₂O (NC)	0.2 ml	56.8 ± 1.93	52.2 ± 1.71 ^a	−8.09	0.017	29.0 ± 0.31	23.6 ± 0.24 ^a	−18.62	0.000
T-80 (NC)	0.2 ml	58.0 ± 1.51	52.4 ± 0.92 ^a	−9.65	0.004	28.8 ± 0.48	23.0 ± 0.44 ^a	−20.13	0.000
CQ	25	56.8 ± 0.96	56.8 ± 0.89*	0.00	0.674	29.8 ± 0.48	33.2 ± 0.37*^a	+11.40	0.000

Keys: Values for the packed cell volume (PCV) and body weight (BW) are presented as mean (M) ± standard error of the mean (SEM); n = 5 (number of mice/group in a single experiment); D0: day 0 (day-of-extract-inoculation); D4 = day 4 (the fifth day pos-extract-inoculation; mg/kg/day: 1mg of extract per one kilogram of mice for one day; NC: negative control; T-80 = Tween-80 (NC for chloroform extract); dH₂O: distilled water (NC for aqueous and methanol extract); CQ: chloroquine phosphate; *: significant compared with that of NC; ^a: significant difference between D0 and D4. **the first value is for the comparison between D0 and D4, the second is with the NC

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