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Table 1 Effects of the stem bark aqueous and methanol extracts of Piptadeniastrum africanum on HCl/ethanol-induced gastric lesions in rats

From: Gastroprotective and ulcer healing effects of piptadeniastrum Africanum on experimentally induced gastric ulcers in rats

Treatment Dose (mg/kg) n US (mm2) US % UI I % Mucus weight (mg)
Distilled water / 6 236.54 ± 1.73 14.04 ± 0.89 6.72 ± 0.32 / 152.27 ± 2.67
Maalox 50 6 67.74 ± 4.41** 4.33 ± 0.37** 4.27 ± 0.12** 80.91 182.25 ± 3.51
Ranitidine 50 6 66.66 ± 9.78** 4.27 ± 0.51** 5.23 ± 0.32** 81.15 130.25 ± 17.10
Aqueous extract of P. africanum 125 6 58.86 ± 5.33** 3.13 ± 0.34** 4.22 ± 0.23** 81.38 127.40 ± 5.20
250 6 2.95 ± 0.76** 0.19 ± 0.05** 2.17 ± 0.17** 98.75 79.17 ± 5.23**
500 6 0.00 ± 0.00** 0.00 ± 0.00** 0.00 ± 0.00pt>** 100.00 181.67 ± 19.22
Methanol extract of P. africanum 125 6 85.74 ± 5.18** 5.16 ± 0.29** 4.59 ± 0.18** 75.83 177.50 ± 4.74
250 6 36.32 ± 5.96** 1.84 ± 0.22** 2.98 ± 0.34** 89.76 157.60 ± 5.42
500 6 8.23 ± 2.40** 0.46 ± 0.13** 2.24 ± 0.30** 96.52 151.67 ± 4.20
  1. n = number of animals per group, US = Ulcer surface, US % = Ulcer surface percentages, UI = Ulcer index, I % = inhibition percentage
  2. **Significant difference at 0,01 in relation to the control group having received distilled water