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Table 1 Effects of the stem bark aqueous and methanol extracts of Piptadeniastrum africanum on HCl/ethanol-induced gastric lesions in rats

From: Gastroprotective and ulcer healing effects of piptadeniastrum Africanum on experimentally induced gastric ulcers in rats

Treatment

Dose (mg/kg)

n

US (mm2)

US %

UI

I %

Mucus weight (mg)

Distilled water

/

6

236.54ā€‰Ā±ā€‰1.73

14.04ā€‰Ā±ā€‰0.89

6.72ā€‰Ā±ā€‰0.32

/

152.27ā€‰Ā±ā€‰2.67

Maalox

50

6

67.74ā€‰Ā±ā€‰4.41**

4.33ā€‰Ā±ā€‰0.37**

4.27ā€‰Ā±ā€‰0.12**

80.91

182.25ā€‰Ā±ā€‰3.51

Ranitidine

50

6

66.66ā€‰Ā±ā€‰9.78**

4.27ā€‰Ā±ā€‰0.51**

5.23ā€‰Ā±ā€‰0.32**

81.15

130.25ā€‰Ā±ā€‰17.10

Aqueous extract of P. africanum

125

6

58.86ā€‰Ā±ā€‰5.33**

3.13ā€‰Ā±ā€‰0.34**

4.22ā€‰Ā±ā€‰0.23**

81.38

127.40ā€‰Ā±ā€‰5.20

250

6

2.95ā€‰Ā±ā€‰0.76**

0.19ā€‰Ā±ā€‰0.05**

2.17ā€‰Ā±ā€‰0.17**

98.75

79.17ā€‰Ā±ā€‰5.23**

500

6

0.00ā€‰Ā±ā€‰0.00**

0.00ā€‰Ā±ā€‰0.00**

0.00ā€‰Ā±ā€‰0.00pt>**

100.00

181.67ā€‰Ā±ā€‰19.22

Methanol extract of P. africanum

125

6

85.74ā€‰Ā±ā€‰5.18**

5.16ā€‰Ā±ā€‰0.29**

4.59ā€‰Ā±ā€‰0.18**

75.83

177.50ā€‰Ā±ā€‰4.74

250

6

36.32ā€‰Ā±ā€‰5.96**

1.84ā€‰Ā±ā€‰0.22**

2.98ā€‰Ā±ā€‰0.34**

89.76

157.60ā€‰Ā±ā€‰5.42

500

6

8.23ā€‰Ā±ā€‰2.40**

0.46ā€‰Ā±ā€‰0.13**

2.24ā€‰Ā±ā€‰0.30**

96.52

151.67ā€‰Ā±ā€‰4.20

  1. nā€‰=ā€‰number of animals per group, USā€‰=ā€‰Ulcer surface, US %ā€‰=ā€‰Ulcer surface percentages, UIā€‰=ā€‰Ulcer index, I %ā€‰=ā€‰inhibition percentage
  2. **Significant difference at 0,01 in relation to the control group having received distilled water