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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Gastroprotective and ulcer healing effects of piptadeniastrum Africanum on experimentally induced gastric ulcers in rats

Fig. 3

Macroscopic and histological study of acetic acid-induced gastric damage in rats. a’ & a: stomach and histological section of a normal control rat: no injuries to the gastric mucosa are seen and the gastric wall is normal. b & b’: stomach and histological section of a ulcer control rat: there is severe destruction of the surface epithelium and necrotic lesions penetrating deeply into mucosa and sub mucosa layer. c & c’: stomach and histological section of rat treated with Maalox (50 mg/kg): the gastric wall appears normally, but there is edema of mucosa and sub mucosa layer. d & d’: stomach and histological section of rat treated ranitidine (50 mg/kg): the gastric wall appears normally with all layers. e & e’: stomach and histological section of rat treated with 125 mg/kg of aqueous extract: there is mild disruption to the sub mucosal layer. f’ & f: stomach and histological section of rat treated with 250 mg/kg aqueous extract: there is moderate disruption to the surface epithelium. g & g’: stomach and histological section of rat treated with 500 mg/kg of aqueous extract: there is mild disruption to sub mucosal layer and edema of the muscle. h & h’: stomach and histological section of rat treated with 125 mg/kg of methanol extract: there is mild disruption to the epithelium surface and the sub mucosal layer and edema of the serosal layer. i & i’: stomach and histological section of rat treated with 250 mg/kg of methanol extract: there is mild disruption to the epithelium surface and edema of submucosal layer and serosal layer. j & j’: stomach and histological section of rat treated with 500 mg/kg of methanol extract: there is moderate disruption to the epithelium surface although the gastric wall appears normally

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