Fig. 4

Effect of Yukyung Karne on the expression of matrix metalloproteinases, cadherin and vimentin in ovarian cancer cells. a SKOV6 cells were treated with Paclitaxel (Pac, 10 nM), Yukyung Karne (YK, 100 μg) or PY [Pac (10 nM) + YK (100 μg)] for 24 h and the activity of MMP2 and MMP9 enzymes was assessed by gelatin zymography. SKOV6 cells were treated as in A for 24 h and the cell lysates were either western blotted (WB) for N- and E-cadherins (b) or quantitated for vimentin mRNA by qRT-PCR (c). The results are represented as mean ± S.D. of three independent experiments. Statistical significance:*, p <0.05