Treatment (Drug/Aqueous Extract) | Dose (mg/kg) | Tail flick reaction time [RT] (sec) and pain inhibition [PI] (%) at designated time intervals (minutes) (x ± SD, n = 5) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | 0 | 30 |  | 60 |  | 90 |  | 120 |  |
 |  | RT | RT | PI | RT | PI | RT | PI | RT | PI |
Paracetamol | 150 | 4.27 ± 0.38 | 6.82 ± 0.28 | 60.0 | 8.39 ± 0.20 | 96.8 | 8.43 ± 0.36 | 97.6 | 8.26 ± 0.23 | 93.5 |
Mangifera indica bark | 300 | 4.30 ± 0.38 | 5.62 ± 0.24 | 31.7 | 6.47 ± 0.37 | 51.7 | 6.30 ± 0.31* | 47.6 | 5.66 ± 0.24* | 32.7 |
600 | 4.30 ± 0.38 | 5.96 ± 0.49 | 39.6 | 6.46 ± 0.37* | 51.5 | 6.35 ± 0.25* | 48.8 | 6.25 ± 0.20* | 46.5 | |
1200 | 4.30 ± 0.38 | 7.20 ± 0.27 | 68.8 | 8.05 ± 0.41 | 88.7 | 6.99 ± 0.29 | 63.8 | 6.98 ± 0.06 | 63.6 | |
Mangifera indica leaf | 300 | 4.32 ± 0.38 | 6.47 ± 0.25 | 51.8 | 7.59 ± 0.43 | 77.9 | 6.19 ± 0.37* | 45.1 | 6.08 ± 0.20* | 42.6 |
600 | 4.32 ± 0.38 | 6.95 ± 0.14 | 62.9 | 7.80 ± 0.21 | 82.2 | 7.78 ± 0.76 | 82.4 | 7.47 | 75.1 | |
1200 | 4.32 ± 0.38 | 7.09 ± 0.48 | 66.1 | 8.89 ± 0.41 | 108.5 | 8.64 ± 0.44 | 102.6 | 8.42 ± 0.36 | 97.3 | |
Psidium guajava leaf | 300 | 4.25 ± 0.38 | 6.32 ± 0.35 | 49.3 | 6.49 ± 0.29 | 52.2 | 6.38 ± 0.17* | 49.6 | 5.26 ± 0.17* | 23.2 |
600 | 4.25 ± 0.38 | 7.63 ± 0.38 | 78.8 | 7.73 ± 0.27 | 81.2 | 7.42 ± 0.46 | 73.8 | 6.45 ± 0.31* | 51.2 | |
1200 | 4.25 ± 0.38 | 7.82 ± 0.35 | 83.3 | 7.88 ± 0.19 | 84.7 | 7.54 ± 0.37 | 76.7 | 7.08 ± 0.05 | 65.9 | |
Carica papaya leaf | 300 | 4.29 ± 0.38 | 5.80 ± 0.70* | 36.1 | 6.35 ± 0.31* | 48.9 | 6.19 ± 0.53* | 45.1 | 5.98 ± 0.17* | 40.2 |
600 | 4.29 ± 0.38 | 6.73 ± 0.87 | 57.8 | 6.65 ± 0.52 | 55.8 | 6.34 ± 0.48* | 48.7 | 6.16 ± 0.27* | 44.4 | |
1200 | 4.29 ± 0.38 | 5.04 ± 0.62* | 18.2 | 5.12 ± 0.39* | 20.1 | 5.39 ± 0.63* | 26.3 | 5.36 ± 0.29* | 25.7 | |
Cymbopogon citratus leaf | 300 | 4.31 ± 0.38 | 5.42 ± 0.50* | 27.0 | 6.22 ± 0.28* | 45.8 | 5.48 ± 0.09 | 28.4 | 5.00 ± 0.38* | 17.3 |
600 | 4.31 ± 0.38 | 6.00 ± 0.90 | 40.6 | 6.43 ± 0.33 | 50.8 | 5.98 ± 0.30* | 40.1 | 5.74 ± 0.38* | 34.5 | |
1200 | 4.31 ± 0.38 | 5.87 ± 0.32 | 37.6 | 6.56 ± 0.41 | 53.7 | 5.80 ± 0.25* | 36.0 | 5.69 ± 0.32* | 33.4 | |
Citrus sinensis leaf | 300 | 4.27 ± 0.38 | 4.76 ± 0.17* | 11.6 | 4.77 ± 0.31** | 11.7 | 4.61 ± 0.32** | 8.0 | 4.30 ± 0.22** | 0.9 |
600 | 4.27 ± 0.38 | 4.92 ± 0.28* | 15.4 | 4.59 ± 0.33** | 7.5 | 4.65 ± 0.42** | 9.1 | 4.35 ± 0.15** | 1.9 | |
1200 | 4.27 ± 0.38 | 4.55 ± 0.30* | 6.7 | 4.35 ± 0.24** | 1.9 | 4.38 ± 0.15** | 2.8 | 4.26 ± 0.22** | 0.0 | |
Ocimum gratissimum leaf | 300 | 4.33 ± 0.38 | 5.58 ± 0.38 | 30.8 | 6.33 ± 0.50* | 48.5 | 6.45 ± 0.26* | 51.2 | 5.85 ± 0.14* | 37.0 |
600 | 4.33 ± 0.38 | 6.03 ± 0.76 | 41.3 | 6.60 ± 0.54 | 54.7 | 7.09 ± 0.68 | 66.1 | 6.19 ± 0.30* | 45.1 | |
1200 | 4.33 ± 0.38 | 7.50 ± 0.55 | 75.9 | 7.81 ± 0.29 | 83.0 | 9.09 ± 0.69 | 113.0 | 7.91 ± 0.38 | 85.5 |