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Table 4 Antinociceptive effect of the constituent plant extracts of Nefang on electric heat-induced pain on the tails of mice

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract)

Dose (mg/kg)

Tail flick reaction time [RT] (sec) and pain inhibition [PI] (%) at designated time intervals (minutes) (x ± SD, n = 5)

  

0

30

 

60

 

90

 

120

 
  

RT

RT

PI

RT

PI

RT

PI

RT

PI

Paracetamol

150

4.27 ± 0.38

6.82 ± 0.28

60.0

8.39 ± 0.20

96.8

8.43 ± 0.36

97.6

8.26 ± 0.23

93.5

Mangifera indica bark

300

4.30 ± 0.38

5.62 ± 0.24

31.7

6.47 ± 0.37

51.7

6.30 ± 0.31*

47.6

5.66 ± 0.24*

32.7

600

4.30 ± 0.38

5.96 ± 0.49

39.6

6.46 ± 0.37*

51.5

6.35 ± 0.25*

48.8

6.25 ± 0.20*

46.5

1200

4.30 ± 0.38

7.20 ± 0.27

68.8

8.05 ± 0.41

88.7

6.99 ± 0.29

63.8

6.98 ± 0.06

63.6

Mangifera indica leaf

300

4.32 ± 0.38

6.47 ± 0.25

51.8

7.59 ± 0.43

77.9

6.19 ± 0.37*

45.1

6.08 ± 0.20*

42.6

600

4.32 ± 0.38

6.95 ± 0.14

62.9

7.80 ± 0.21

82.2

7.78 ± 0.76

82.4

7.47

75.1

1200

4.32 ± 0.38

7.09 ± 0.48

66.1

8.89 ± 0.41

108.5

8.64 ± 0.44

102.6

8.42 ± 0.36

97.3

Psidium guajava leaf

300

4.25 ± 0.38

6.32 ± 0.35

49.3

6.49 ± 0.29

52.2

6.38 ± 0.17*

49.6

5.26 ± 0.17*

23.2

600

4.25 ± 0.38

7.63 ± 0.38

78.8

7.73 ± 0.27

81.2

7.42 ± 0.46

73.8

6.45 ± 0.31*

51.2

1200

4.25 ± 0.38

7.82 ± 0.35

83.3

7.88 ± 0.19

84.7

7.54 ± 0.37

76.7

7.08 ± 0.05

65.9

Carica papaya leaf

300

4.29 ± 0.38

5.80 ± 0.70*

36.1

6.35 ± 0.31*

48.9

6.19 ± 0.53*

45.1

5.98 ± 0.17*

40.2

600

4.29 ± 0.38

6.73 ± 0.87

57.8

6.65 ± 0.52

55.8

6.34 ± 0.48*

48.7

6.16 ± 0.27*

44.4

1200

4.29 ± 0.38

5.04 ± 0.62*

18.2

5.12 ± 0.39*

20.1

5.39 ± 0.63*

26.3

5.36 ± 0.29*

25.7

Cymbopogon citratus leaf

300

4.31 ± 0.38

5.42 ± 0.50*

27.0

6.22 ± 0.28*

45.8

5.48 ± 0.09

28.4

5.00 ± 0.38*

17.3

600

4.31 ± 0.38

6.00 ± 0.90

40.6

6.43 ± 0.33

50.8

5.98 ± 0.30*

40.1

5.74 ± 0.38*

34.5

1200

4.31 ± 0.38

5.87 ± 0.32

37.6

6.56 ± 0.41

53.7

5.80 ± 0.25*

36.0

5.69 ± 0.32*

33.4

Citrus sinensis leaf

300

4.27 ± 0.38

4.76 ± 0.17*

11.6

4.77 ± 0.31**

11.7

4.61 ± 0.32**

8.0

4.30 ± 0.22**

0.9

600

4.27 ± 0.38

4.92 ± 0.28*

15.4

4.59 ± 0.33**

7.5

4.65 ± 0.42**

9.1

4.35 ± 0.15**

1.9

1200

4.27 ± 0.38

4.55 ± 0.30*

6.7

4.35 ± 0.24**

1.9

4.38 ± 0.15**

2.8

4.26 ± 0.22**

0.0

Ocimum gratissimum leaf

300

4.33 ± 0.38

5.58 ± 0.38

30.8

6.33 ± 0.50*

48.5

6.45 ± 0.26*

51.2

5.85 ± 0.14*

37.0

600

4.33 ± 0.38

6.03 ± 0.76

41.3

6.60 ± 0.54

54.7

7.09 ± 0.68

66.1

6.19 ± 0.30*

45.1

1200

4.33 ± 0.38

7.50 ± 0.55

75.9

7.81 ± 0.29

83.0

9.09 ± 0.69

113.0

7.91 ± 0.38

85.5

  1. Significant difference * - p < 0.05, ** - p < 0.001 when compared to the standard control