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Table 2 Effect of the aqueous extracts of the constituent plants of Nefang on Brewer’s Yeast-induced hyperpyrexia in wistar rats

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract)

Dose (mg/kg)

Basal Temperature

Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes)

\( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \)

   

30

 

60

 

120

 

180

 

240

 
   

BT

PI

BT

PI

BT

PI

BT

PI

BT

PI

Normal Saline

-

37.00 ± 0.29

37.95 ± 0.21

0.0

38.14 ± 0.38

0.0

38.65 ± 0.32

0.0

38.91 ± 0.11

0.0

38.96 ± 0.54

0

Paracetamol

150

36.90 ± 0.38

37.70 ± 0.45

15.8

37.75 ± 0.33

25.4

37.85 ± 0.28*

42.4

37.47 ± 0.26*

70.2

37.00 ± 0.39**

94.9

Mangifera indica bark

200

36.90 ± 0.31

37.85 ± 0.39

0.0

37.90 ± 0.41

12.3

37.75 ± 0.27*

48.5

37.55 ± 0.25*

66.0

37.20 ± 0.41*

84.7

 

400

36.95 ± 0.92

37.95 ± 0.27

0.0

38.15 ± 0.54

0.0

37.73 ± 0.31*

52.7

37.50 ± 0.19*

71.2

37.30 ± 0.38*

82.1

Mangifera indica leaf

200

37.00 ± 0.74

37.85 ± 0.16

10.5

37.95 ± 0.37

16.7

37.60 ± 0.18*

63.6

37.35 ± 0.11*

81.7

37.20 ± 0.28*

89.8

400

37.05 ± 0.67

38.45 ± 0.43

0.0

38.60 ± 0.29

0.0

38.25 ± 0.17*

27.3

37.90 ± 0.28*

55.5

37.50 ± 0.19*

77.0

Psidium guajava leaf

200

36.95 ± 0.51

38.00 ± 0.54

0.0

38.40 ± 0.61

0.0

38.70 ± 0.19

0.0

38.65 ± 0.38

11.0

38.50 ± 0.17

20.9

400

37.10 ± 0.33

38.00 ± 0.15

5.3

38.65 ± 0.72

0.0

38.75 ± 0.24

0.0

38.55 ± 0.36

24.1

38.45 ± 0.11

31.1

Carica papaya leaf

200

37.00 ± 0.61

38.25 ± 0.27

0.0

38.60 ± 0.36

0.0

38.68 ± 0.22

0.0

38.65 ± 0.31

13.6

38.60 ± 0.26

18.4

400

36.90 ± 0.68

37.90 ± 0.51

0.0

38.45 ± 0.29

0.0

38.65 ± 0.31

0.0

38.70 ± 0.29

5.8

38.60

13.3

Cymbopogon citratus leaf

200

36.95 ± 0.28

37.90 ± 0.89

0.0

37.85 ± 0.18

21.1

37.45 ± 0.35*

69.7

37.20 ± 0.52*

86.9

37.00 ± 0.09**

97.4

400

37.00 ± 0.41

38.05 ± 0.62

0.0

37.70 ± 0.09

38.6

37.45 ± 0.18*

72.7

37.30 ± 0.56*

84.3

37.05 ± 0.22**

97.4

Citrus sinensis leaf

200

37.00 ± 0.22

38.00 ± 0.20

0.0

38.05 ± 0.25

7.9

37.85 ± 0.26*

48.5

37.55 ± 0.19*

71.2

37.35 ± 0.35*

82.1

400

37.05 ± 0.15

38.05 ± 0.31

0.0

38.25 ± 0.18

0.0

37.75 ± 0.11*

57.6

37.45 ± 0.55*

79.1

37.25 ± 0.28*

89.8

Ocimumgratissimum leaf

200

37.00 ± 0.33

37.95 ± 0.46

0.0

37.90 ± 0.42

21.1

37.75 ± 0.19*

54.5

37.40 ± 0.38*

79.1

37.15 ± 0.52**

92.3

400

37.00 ± 0.81

37.95 ± 0.19

0.0

38.00 ± 0.19

12.3

37.75 ± 0.09*

54.5

37.45 ± 0.61*

76.4

37.10 ± 0.33**

94.9

  1. Significant difference * - p < 0.05, ** - p < 0.001 when compared to the control