Treatment (Drug/Aqueous Extract) | Dose (mg/kg) | Basal Temperature | Body temperature [BT] (°C) and pyrexia inhibition [PI] (%) over time (minutes) \( \left(\overline{\mathrm{x}}\pm \mathrm{S}\mathrm{D},\kern0.5em \mathrm{n}=4\right) \) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  | 30 |  | 60 |  | 120 |  | 180 |  | 240 |  |
 |  |  | BT | PI | BT | PI | BT | PI | BT | PI | BT | PI |
Normal Saline | - | 34.95 ± 0.33 | 35.78 ± 0.19 | 0.0 | 36.23 ± 0.32 | 0.0 | 36.70 ± 0.38 | 0.0 | 36.78 ± 0.39 | 0.0 | 36.98 ± 0.33 | 0.0 |
Paracetamol | 150 | 34.98 ± 0.42 | 35.85 ± 0.24 | 15.5 | 36.18 ± 0.28 | 15.9 | 36.08 ± 0.19* | 37.1 | 35.28 ± 0.29* | 78.1 | 34.98 ± 0.17** | 100.0 |
Mangifera indica bark | 200 | 35.03 ± 0.10 | 36.40 ± 0.14 | 0.0 | 35.90 ± 0.22 | 31.4 | 35.60 ± 0.16* | 67.1 | 35.45 ± 0.13* | 76.7 | 35.25 ± 0.33* | 88.9 |
400 | 35.00 ± 0.08 | 36.55 ± 0.21 | 0.0 | 36.03 ± 0.15 | 19.6 | 35.68 ± 0.22* | 61.4 | 35.45 ± 0.17* | 75.3 | 35.33 ± 0.24* | 84.0 | |
Mangifera indica leaf | 200 | 35.00 ± 0.18 | 36.05 ± 0.13 | 0.0 | 35.98 ± 0.19 | 23.5 | 35.75 ± 0.29* | 57.1 | 35.43 ± 0.17* | 76.7 | 35.25 ± 0.26* | 87.7 |
400 | 35.18 ± 0.34 | 36.80 ± 0.24 | 0.0 | 36.78 ± 0.10 | 0.0 | 36.08 ± 0.10* | 48.6 | 35.85 ± 0.45* | 63.0 | 35.38 ± 0.37* | 90.1 | |
Psidium guajava leaf | 200 | 35.18 ± 0.39 | 36.13 ± 0.26 | 0.0 | 36.35 ± 0.37 | 7.8 | 36.80 ± 0.14 | 7.1 | 36.63 ± 0.19 | 20.5 | 36.45 ± 0.06 | 37.0 |
400 | 35.15 ± 0.21 | 36.05 ± 0.19 | 0.0 | 36.50 ± 0.54 | 0.0 | 36.68 ± 0.13 | 12.9 | 36.40 ± 0.14 | 31.5 | 36.45 ± 0.33 | 35.8 | |
Carica papaya leaf | 200 | 35.05 ± 0.48 | 36.48 ± 0.61 | 0.0 | 36.53 ± 0.43 | 0.0 | 36.78 ± 0.49 | 1.4 | 36.80 ± 0.48 | 4.1 | 36.68 ± 0.39 | 19.8 |
400 | 35.00 ± 0.35 | 36.45 ± 0.52 | 0.0 | 36.63 ± 0.93 | 0.0 | 36.70 ± 0.22 | 2.9 | 36.75 ± 0.52 | 4.1 | 36.75 ± 0.37 | 13.6 | |
Cymbopogon citratus leaf | 200 | 35.05 ± 0.17 | 36.10 ± 0.08 | 0.0 | 35.88 ± 0.22 | 35.3 | 35.50 ± 0.38* | 74.3 | 35.20 ± 0.41* | 91.8 | 35.15 ± 0.17** | 95.1 |
400 | 34.90 ± 0.29 | 35.85 ± 0.06 | 0.0 | 35.75 ± 0.25 | 33.3 | 35.43 ± 0.33* | 70.0 | 35.23 ± 0.42* | 82.2 | 35.20 ± 0.18** | 85.2 | |
Citrus sinensis leaf | 200 | 34.90 ± 0.08 | 35.73 ± 0.13 | 0.0 | 36.05 ± 0.13 | 9.8 | 35.73 ± 0.15* | 52.9 | 35.50 ± 0.12* | 67.1 | 35.28 ± 0.22** | 81.5 |
400 | 34.98 ± 0.15 | 35.93 ± 0.10 | 0.0 | 36.08 ± 0.28 | 13.7 | 35.88 ± 0.15* | 48.6 | 35.58 ± 0.32* | 67.1 | 35.33 ± 0.22** | 82.7 | |
Ocinum gratissimum leaf | 200 | 34.93 ± 0.13 | 35.63 ± 0.36 | 15.1 | 35.80 ± 0.36 | 31.4 | 35.58 ± 0.36* | 62.9 | 35.28 ± 0.66* | 80.8 | 35.28 ± 0.71** | 82.7 |
400 | 34.90 ± 0.16 | 35.95 ± 0.17 | 0.0 | 36.05 ± 0.17 | 9.8 | 35.88 ± 0.13* | 44.3 | 35.25 ± 0.32* | 80.8 | 35.20 ± 0.22** | 85.2 |