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Table 2 FIC indices combination of fraction F-10 of D. grandiflora leaf extract with ampicillin against MRSA ATCC 43300. Values represent triplicates of three independent experiments

From: Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of ampicillin and a bioactive fraction from Duabanga grandiflora

MIC of F-10 (mg/L)

MIC of ampicillin in combination (mg/L)

aFIC index

0

50

-

1/4 × MIC (188)

0.78

0.25

1/8 × MIC (94)

3.13

0.18

1/16 × MIC (47)

12.5

0.31

1/32 × MIC (23)

12.5

0.28

  1. aFIC index; synergism ≤ 0.5, indifference >0.5 but ≤ 4.0, and antagonism > 4