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Fig. 6 | BMC Complementary and Alternative Medicine

Fig. 6

From: Effects of rhodiola crenulata on mice hearts under severe sleep apnea

Fig. 6

Our hypothesis that Rhodiola Crenulata suppressed chronic intermittent hypoxia-induced cardiac Fas-dependent, mitochondria-dependent apoptotic pathways and enhanced chronic intermittent hypoxia-induced cardiac VEGF-related pro-survival pathway. The data is based on chronic intermittent hypoxia increases in pro-apoptotic Fas, FADD, activated caspase 8, activated caspase 3 (left pathway, Fas-dependent apoptotic pathway), and chronic intermittent hypoxia decreases anti-apoptotic Bcl-xL, Bcl-2, and p-Bad, increases t-Bid, Bad, Bax, activated caspase-9, and activated caspase-3 (middle pathway, mitochondria-dependent apoptotic pathway), and chronic intermittent hypoxia increased pro-survival protein VEGF, p-PI3k and p-AKT (right pathway, pro-survival VEGF-related pathway). Rhodiola Crenulata decreases chronic intermittent hypoxia-induced cardiac Fas-dependent and mitochondrial-dependent apoptotic pathways, but increases chronic intermittent hypoxia-induced cardiac VEGF-related pro-survival pathway. The upward arrows and downward arrows represent the respective increases and decreases

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