Table 2 Significantly Changed Genes (different doses common raised) Mapped to KEGG Pathways

Cell adhesion molecules (CAMs)

13

9.35E-12

6.95E-11

Cdh1;RT1-N3;Cd8a;Jam3;Itgb7;Cd274;Cldn5;Cd8b;

Icam2;H2-T24;Itgam;Itgb2;Cldn4

Natural killer cell mediated cytotoxicity

12

8.04E-11

3.78E-10

Rac2;RT1-N3;Ptpn6;Lck;Grb2;Zap70;Icam2;H2-T24;

Tyrobp;Fcgr3;Itgb2;Prf1

Focal adhesion

13

1.61E-10

6.43E-10

Rac2;Fn1;Col5a1;Grb2;Itgb7;Fn1;Col1a2;Col1a1;

Col4a2;Col1a1;Col4a1;Tnn;Flna;Ccnd1;Myl9

Complement and coagulation cascades

9

3.42E-10

1.27E-09

C1qb;C4b

;C1qa;C1r

;C1s;Cfb;

C2;C6;Plau

ECM-receptor interaction

8

1.55E-08

3.84E-08

Fn1;Col5a1;Itgb7;Fn1;Col1a2;Col1a1;Col4a2;

Col1a1;Col4a1;Tnn

Leukocyte transendothelial migration

9

4.12E-08

8.92E-08

Rac2;Jam3;Cldn5;Thy1;Itgam;Itgb2;Cxcr4;Myl9;Cldn4

Primary immunodeficiency

6

6.53E-08

1.36E-07

Cd8a;Ciita;Lck;Zap70;Rfxap;Cd8b

Arachidonic acid metabolism

6

1.61E-06

2.61E-06

Ephx2;Cyp2j4;Gpx3;Ptgs1;Pla2g10;Cbr1

Systemic lupus erythematosus

8

2.56E-06

4.04E-06

C1qb;C4b;C1qa;C1r;C1s;C2;C6;Fcgr3

Antigen processing and presentation

7

2.92E-06

4.22E-06

RT1-N3;Cd8a;Ciita;Rfxap;Cd8b;H2-T24;Cd74

Regulation of actin cytoskeleton

9

5.00E-06

7.03E-06

Cfl1;LOC688430;Rac2;Fn1;Pip4k2a;Itgb7;Fn1;

Itgam;Itgb2;Myl9

T cell receptor signaling pathway

6

6.53E-05

7.54E-05

Cd8a;Ptpn6;Lck;Grb2;Zap70;Cd8b

Hematopoietic cell lineage

5

1.02E-04

1.09E-04

Cd8a;Csf1r;Anpep;Cd8b;Itgam

Axon guidance

6

1.25E-04

1.30E-04

Cfl1;LOC688430;Rac2;Slit3;Fes;Cxcr4

Small cell lung cancer

5

2.92E-04

2.62E-04

Fn1;Nos3;Fn1;Col4a2;Col4a1;Ccnd1

Citrate cycle (TCA cycle)

3

7.92E-04

6.44E-04

Pck1;Aco1;Acly