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Table 2 Effect of different extracts of Kaempferia galanga on hole cross test in mice

From: Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice

Group

Dose (mg/kg)

Number of movements (% of Number of movements inhibition)

0 min

30 min

60 min

90 min

120 min

Control

5 ml/kg

15.5 ± 1.84

14.33 ± 2.18

13.67 ± 1.83

10.5 ± 1.03

10 ± 1.41

Diazepam

2

15 ± 1.09

7.34 ± 0.76 (48.78 %)

4.67 ± 0.61** (65.83 %)

3.83 ± 0.75** (63.53 %)

2.83 ± 0.59** (71.70 %)

ACR

100

7.5 ± 2.36

2.83 ± 1.01** (80.25 %)

2.33 ± 0.76** (82.95 %)

1.83 ± 0.47** (82.57 %)

3.33 ± 1.31* (66.7 %)

200

9.67 ± 1.76

1.83 ± 0.31** (87.23 %)

0.83 ± 0.31** (93.93 %)

1.5 ± 0.43** (85.72 %)

1.67 ± 0.88** (83.3 %)

PEF

100

11.33 ± 2.47

1.17 ± 0.31** (91.83 %)

1.17 ± 0.40** (91.44 %)

2 ± 0.82** (80.95 %)

2.5 ± 1.05** (75 %)

200

8 ± 1.31

1 ± 0.26** (93.02 %)

0.83 ± 0.47** (93.93 %)

1.67 ± 0.61** (84.09 %)

1.17 ± 0.60** (88.3 %)

CHF

100

10.83 ± 0.65

4.83 ± 3.26* (66.29 %)

2.5 ± 1.70** (81.71 %)

3.67 ± 0.84** (65.05 %)

2.17 ± 0.60** (78.3 %)

200

11.17 ± 3.09

4.5 ± 1.41* (68.59 %)

1.83 ± 1.07** (86.61 %)

1.5 ± 0.95** (85.71 %)

0.67 ± 0.33** (93.3 %)

MEF

100

8 ± 1.41

5.67 ± 2.82* (60.43 %)

2 ± 1.06** (85.37 %)

1.33 ± 0.71** (87.33 %)

1.67 ± 0.61** (83.3 %)

200

11 ± 1.21

2.83 ± 1.19* (80.25 %)

1.83 ± 0.54** (86.61 %)

1.33 ± 0.49** (87.33 %)

1.5 ± 0.50** (85.00 %)

ACL

100

9.67 ± 1.99

2.5 ± 0.72** (82.55 %)

2.67 ± 0.95** (80.47 %)

2.5 ± 0.67** (76.19 %)

1.83 ± 4.00** (81.7 %)

200

6.83 ± 2.01

1.33 ± 0.95** (90.72 %)

0.67 ± 0.49** (95.09 %)

1 ± 0.52** (90.47 %)

0.5 ± 0.34** (95.00 %)

  1. Control group received water 5 ml/kg body weight (p.o.), standard group received Diazepam 2 mg/kg body weight (i.p.), test groups ACR, PEF, CHF, MEF and ACL were treated with 100 and 200 mg/kg body weight of the extracts (p.o.) respectively. Values are mean ± SEM, (n = 6); * p < 0.05, **p < 0.001, Dunnett t-test as compared to control. ACR = Acetone extract of rhizome, PEF = Petroleum ether fraction of rhizome, CHF = Chloroform fraction of rhizome, MEF = Methanol fraction of rhizome and ACL = Acetone extract of leaf