Table 2 Effect of Karapxa decoction (KD) or Allopurinol (AP) on serum uric acid (UA) and liver xanthine oxidase (XO) activity in yeast extract paste (YEP) and potassium oxonate (PO) models of hyperuricemic mice in vivo
Group | Dose | UA | UA inhibition | Liver XO | Liver XO inhibition |
|---|---|---|---|---|---|
(mg/kg) | (μmol/L) | (%) | (U/per mg protein) | (%) | |
Normal | -- | 6.12 ± 2.12 | -- | 1.84 ± 0.15 | -- |
Model (YEP) | -- | 135.5 ± 29.2Δ | -- | 3.59 ± 0.28Δ | -- |
YEP + KD | 200 | 96.7 ± 27.8** | 28.6 | 3.05 ± 0.21* | 15.0 |
YEP + KD | 400 | 81.8 ± 22.9** | 39.6 | 2.65 ± 0.13* | 26.2 |
YEP + KD | 800 | 65.5 ± 15.9** | 51.6 | 2.15 ± 0.22** | 40.1 |
YEP + AP | 10 | 15.0 ± 3.0** | 88.9 | 1.28 ± 0.25** | 64.3 |
Normal | -- | 9.53 ± 1.42 | -- | 1.62 ± 0.23 | -- |
Model (PO) | -- | 243.1 ± 17.2Δ | -- | 3.86 ± 0.31Δ | -- |
PO + KD | 200 | 196.3 ± 22.8** | 19.2 | 3.15 ± 0.31 | 18.4 |
PO + KD | 400 | 162.5 ± 21.0** | 33.2 | 2.81 ± 0.13* | 27.2 |
PO + KD | 800 | 135.5 ± 15.6** | 44.3 | 2.65 ± 0.22* | 31.4 |
PO + AP | 10 | 25.0 ± 19.0** | 89.7 | 1.48 ± 0.15** | 61.7 |