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Table 1 Effects of MEMM on the parameters of gastric juice and on gastric wall mucus content obtained from pylorus-ligature rats

From: Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves

Model

Treatment

Dose, (mg/kg)

Gastric juice

Gastric wall mucus

Volume (ml)

pH

Total acidity (meq/l)

Free acidity (meq/l)

Alcian blueμg/g wet tissue

Pylorus ligation

10% DMSO

-

5.83 ± 1.01

1.50 ± 0.09

5427.00 ± 380.40

4367.00 ± 573.30

85.68 ± 13.76

Ranitidine

100

1.63 ± 0.30a

4.41 ± 0.76b

1433.00 ± 92.15c

1500.00 ± 235.20d

241.30 ± 14.11*

MEMM

50

6.50 ± 0.52

1.82 ± 0.12

3100.00 ± 392.30c

2420.00 ± 438.80d

151.26 ± 32. 17*

250

2.58 ± 0.61a

2.43 ± 0.22b

3107.00 ± 458.00c

2040.00 ± 327.60d

354.24 ± 38.71*

500

1.95 ± 0.16a

3.55 ± 0.63b

3105.00 ± 435.2c

933.30 ± 291.90d

422.08 ± 67.73*

Quercitrin

50

4.31 ± 0.74a

2.38 ± 0.23b

4648.00 ± 223.50c

3211.00 ± 261.60d

258.63 ± 17.48*

250

4.72 ± 0.38a

4.43 ± 0.16b

3519.00 ± 380.40c

2367.00 ± 382.80d

407.42 ± 21.76*

  1. a,b,c,d,Data with different superscript differed significantly (p < 0.05) when compared to the 10% DMSO-pretreated group within the respective column.
  2. *Data differed significantly (p < 0.05) when compared to the 10% DMSO-pretreated group within the respective column.