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Table 4 Effect of pantoprazole and lycopene on immunoregulatory cytokines in esophageal tissues of experimental animals

From: Effect of lycopene against gastroesophageal reflux disease in experimental animals

S. No.

Treatment

IL-1β (pg/ml)

IL-6 (pg/ml)

Group-I

Sham control (Normal saline,3 ml/kg,p.o)

758.98 ± 30.61***

17673.16 ± 196.4***

Group-II

Esophagitis control (Normal saline,3 ml/kg,p.o)

2595.9 ± 210.93

43429.33 ± 868.9

Group-III

Lycopene (50 mg/kg,p.o)

755.68 ± 82.67***

25878.2 ± 405.1***

Group-IV

Lycopene (100 mg/kg,p.o)

788.86 ± 38.19***

22055.31 ± 779.86***c

Group-V

Pantoprazole (30 mg/kg,p.o)

612.98 ± 44.47***

15611.14 ± 411.82***

  1. Each group contains six animals. Values are represented as mean ± SD. Statistical significance compared to toxic control using one-way ANOVA followed by Bonferroni test (***P < 0.001).
  2. Statistical significance compared between lycopene (50 mg/kg) and lycopene (100 mg/kg) using one-way ANOVA followed by Bonferroni test (c P < 0.001).