Table 5 Biochemical parameters of rats in sub-acute toxicity of the methylene/chloride extract of S. barteri

Urinary creatinine (mg/dl)

38.64 ± 3.80^a

37.76 ± 3.28^a

37.44 ± 3.14^a

30.96 ± 1.07^b

28.96 ± 3.40^b

Serum creatinine (mg/dl)

21.04 ± 1.02^a

24.60 ± 2.47^a

24.80 ± 4.01^a

24.80 ± 4.01^a

24.84 ± 3.20^a

Total cholesterol (mg/dl)

122.30 ± 3.37^a

122.80 ± 3.47^a

121.92 ± 5.14^a

121.84 ± 2.65^a

121.73 ± 1.78^a

Male

HDL cholesterol (mg/dl)

90.42 ± 7.31^a

90.73 ± 7.18^a

90.95 ± 6.51^a

92.86 ± 4.39^a

93.73 ± 5.12^a

LDL cholesterol (mg/dl)

4.15 ± 0.60^a

4.31 ± 1.56^a

3.45 ± 1.23^ab

1.41 ± 0.29^b

1.40 ± 0.17^b

Triglycerides (mg/dl)

141.62 ± 5.38^a

138.80 ± 8.20^a

137.60 ± 3.10^a

137.82 ± 0.35^a

133.00 ± 3.15^a

ALT(U/L)

45.88 ± 1.56^c

52.00 ± 2.19^b

54.43 ± 7.36^b

66.07 ± 5.78^a

66.24 ± 5.29^a

AST (U/L)

7.60 ± 1.10^b

9.65 ± 0.95^ab

9.77 ± 0.73^a

9.79 ± 2.50^a

9.91 ± 0.63^a

Serum protein (mg/dl)

8.35 ± 0.32^c

8.68 ± 1.22^c

11.37 ± 1.83^b

13.73 ± 0.79^a

14.66 ± 1.76^a

Urinary protein (mg/dl)

3.48 ± 0.81^a

3.42 ± 0.29^a

3.35 ± 0.45^a

3.09 ± 0.56^a

3.06 ± 0.83^a

Hepatic protein (mg/g)

562.12 ± 71.22^a

436.16 ± 39.54^b

348.67 ± 24.80^c

273.41 ± 33.30^d

282.62 ± 32.76^d

Spleen protein (mg/g)

332.00 ± 31.87^a

291.01 ± 27.49^ab

290.00 ± 32.62^ab

280.00 ± 26.53^b

280.00 ± 29.60^b

Testis protein (mg/g)

87.10 ± 11.07^a

84.48 ± 5.43^a

63.74 ± 13.74^b

54.69 ± 8.33^b

53.49 ± 4.25^b

Urinary creatinine (mg/dl)

64.32 ± 6.16^a

63.24 ± 5.06^a

54.52 ± 2.30^b

48.68 ± 3.30^c

48.40 ± 0.35^c

Serum creatinine (mg/dl)

31.08 ± 3.00^a

31.44 ± 1.20^a

31.44 ± 2.79^a

31.04 ± 2.10^a

31.68 ± 1.24^a

Total cholesterol (mg/dl)

119.60 ± 2.58^a

121.73 ± 5.15^a

121.73 ± 5.15^a

122.34 ± 3.01^a

122.59 ± 4.99^a

Female

HDL cholesterol (mg/dl)

71.61 ± 3.35 ^b

73.26 ± 1.18^b

77.41 ± 7.43^b

96.44 ± 2.72^a

94.44 ± 7.77^a

LDL cholesterol (mg/dl)

26.98 ± 5.44^a

30.98 ± 5.10^a

28.71 ± 4.39^a

13.05 ± 2.57^b

12.16 ± 2.48^b

Triglycerides (mg/dl)

96.60 ± 8.90^a

87.40 ± 7.67^a

87.00 ± 9.78^a

71.80 ± 8.08^b

68.81 ± 4.00^b

ALT(U/L)

42.58 ± 9.10^b

49.57 ± 2.82^a

49.60 ± 5.37^a

49.65 ± 8.94^a

49.91 ± 4.38^a

AST (U/L)

9.10 ± 0.80^c

9.58 ± 0.76^bc

10.38 ± 1.36^b

11.96 ± 0.99^a

12.61 ± 0.99^a

Serum protein (mg/dl)

7.13 ± 0.61^b

8.10 ± 0.20^b

12.56 ± 0.97^a

12.79 ± 1.0 ^a

13.34 ± 0.83^a

Urinary protein (mg/dl)

3.30 ± 10.59^a

3.23 ± 0.37^a

3.33 ± 0.14^a

3.35- ± 0.17^a

3.34 ± 0.56^a

Hepatic protein (mg/g)

645.02 ± 19.55^a

527.62 ± 36.79^b

380.26 ± 26.11^c

359.04 ± 43.43^c

350.88 ± 27.47^c

Spleen protein (mg/g)

335.20 ± 34.45^a

284.00 ± 26.08^b

288.00 ± 27.27^b

272.40 ± 37.64^b

268.00 ± 17.44^b

Ovaries protein (mg/g)

546.00 ± 39.77^a

480.00 ± 84.85^ab

451.20 ± 31.29 ^b

449.30 ± 44.18^b

416.68 ± 24.99^b