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Table 5 Biochemical parameters of rats in sub-acute toxicity of the methylene/chloride extract of S. barteri

From: Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae)

  Parameters studied control 100 mg/kg 200 mg/kg 400 mg/kg 800 mg/kg
  Urinary creatinine (mg/dl) 38.64 ± 3.80a 37.76 ± 3.28a 37.44 ± 3.14a 30.96 ± 1.07b 28.96 ± 3.40b
  Serum creatinine (mg/dl) 21.04 ± 1.02a 24.60 ± 2.47a 24.80 ± 4.01a 24.80 ± 4.01a 24.84 ± 3.20a
  Total cholesterol (mg/dl) 122.30 ± 3.37a 122.80 ± 3.47a 121.92 ± 5.14a 121.84 ± 2.65a 121.73 ± 1.78a
Male HDL cholesterol (mg/dl) 90.42 ± 7.31a 90.73 ± 7.18a 90.95 ± 6.51a 92.86 ± 4.39a 93.73 ± 5.12a
  LDL cholesterol (mg/dl) 4.15 ± 0.60a 4.31 ± 1.56a 3.45 ± 1.23ab 1.41 ± 0.29b 1.40 ± 0.17b
  Triglycerides (mg/dl) 141.62 ± 5.38a 138.80 ± 8.20a 137.60 ± 3.10a 137.82 ± 0.35a 133.00 ± 3.15a
  ALT(U/L) 45.88 ± 1.56c 52.00 ± 2.19b 54.43 ± 7.36b 66.07 ± 5.78a 66.24 ± 5.29a
  AST (U/L) 7.60 ± 1.10b 9.65 ± 0.95ab 9.77 ± 0.73a 9.79 ± 2.50a 9.91 ± 0.63a
  Serum protein (mg/dl) 8.35 ± 0.32c 8.68 ± 1.22c 11.37 ± 1.83b 13.73 ± 0.79a 14.66 ± 1.76a
  Urinary protein (mg/dl) 3.48 ± 0.81a 3.42 ± 0.29a 3.35 ± 0.45a 3.09 ± 0.56a 3.06 ± 0.83a
  Hepatic protein (mg/g) 562.12 ± 71.22a 436.16 ± 39.54b 348.67 ± 24.80c 273.41 ± 33.30d 282.62 ± 32.76d
  Spleen protein (mg/g) 332.00 ± 31.87a 291.01 ± 27.49ab 290.00 ± 32.62ab 280.00 ± 26.53b 280.00 ± 29.60b
  Testis protein (mg/g) 87.10 ± 11.07a 84.48 ± 5.43a 63.74 ± 13.74b 54.69 ± 8.33b 53.49 ± 4.25b
  Urinary creatinine (mg/dl) 64.32 ± 6.16a 63.24 ± 5.06a 54.52 ± 2.30b 48.68 ± 3.30c 48.40 ± 0.35c
  Serum creatinine (mg/dl) 31.08 ± 3.00a 31.44 ± 1.20a 31.44 ± 2.79a 31.04 ± 2.10a 31.68 ± 1.24a
  Total cholesterol (mg/dl) 119.60 ± 2.58a 121.73 ± 5.15a 121.73 ± 5.15a 122.34 ± 3.01a 122.59 ± 4.99a
Female HDL cholesterol (mg/dl) 71.61 ± 3.35 b 73.26 ± 1.18b 77.41 ± 7.43b 96.44 ± 2.72a 94.44 ± 7.77a
  LDL cholesterol (mg/dl) 26.98 ± 5.44a 30.98 ± 5.10a 28.71 ± 4.39a 13.05 ± 2.57b 12.16 ± 2.48b
  Triglycerides (mg/dl) 96.60 ± 8.90a 87.40 ± 7.67a 87.00 ± 9.78a 71.80 ± 8.08b 68.81 ± 4.00b
  ALT(U/L) 42.58 ± 9.10b 49.57 ± 2.82a 49.60 ± 5.37a 49.65 ± 8.94a 49.91 ± 4.38a
  AST (U/L) 9.10 ± 0.80c 9.58 ± 0.76bc 10.38 ± 1.36b 11.96 ± 0.99a 12.61 ± 0.99a
  Serum protein (mg/dl) 7.13 ± 0.61b 8.10 ± 0.20b 12.56 ± 0.97a 12.79 ± 1.0 a 13.34 ± 0.83a
  Urinary protein (mg/dl) 3.30 ± 10.59a 3.23 ± 0.37a 3.33 ± 0.14a 3.35- ± 0.17a 3.34 ± 0.56a
  Hepatic protein (mg/g) 645.02 ± 19.55a 527.62 ± 36.79b 380.26 ± 26.11c 359.04 ± 43.43c 350.88 ± 27.47c
  Spleen protein (mg/g) 335.20 ± 34.45a 284.00 ± 26.08b 288.00 ± 27.27b 272.40 ± 37.64b 268.00 ± 17.44b
  Ovaries protein (mg/g) 546.00 ± 39.77a 480.00 ± 84.85ab 451.20 ± 31.29 b 449.30 ± 44.18b 416.68 ± 24.99b
  1. Data are expressed as mean ± S.E.M. n = 5. Values for a given group in a line followed by different letter as superscript are significantly different according to Waller Duncan’s multiple comparison test (P < 0.05). ALT = alanine transaminase; AST = Aspartate transaminase; HDL = high density lipoprotein; LDL = low density lipoprotein.