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Table 2 Effect of oral administration of TAF- Cs, and loperamide on castor oil induced diarrhea in mice

From: Cissampelos sympodialis Eichl. (Menispermaceae), a medicinal plant, presents antimotility and antidiarrheal activity in vivo

Treatment (v.o.)

Dose (mg/kg)

Evacuation Index (EI)

12 % Tween 80 solution

-

15.0 (10.0 - 23.0)

Loperamide

5

0.0 (0.9 - 2.0)***

TAF-Cs

62.5

13.5 (6.0 - 16.0)

TAF-Cs

125

6.0 (4.0 - 8.0)

TAF-Cs

250

1.0 (0.0 - 5.0)**

TAF-Cs

500

1.0 (0.0 - 2.0)**

  1. Data are presented as median (minimum value – maximum value). Kruskal-Wallis test followed by Dunn’s multiple comparison test (** p <0.05, *** p <0.001 compared to the 12% Tween solution group). The TAF-Cs reduced evacuation index (250 and 500 mg/kg) compared to control group (12% Tween 80 solution).