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Table 3 Effect of ZO-ActFr (50 mg/kg) or standard MCP (30 mg/kg) administered 30 mins before cisplatin challenge, on the level of neurotransmitters and their metabolites (ng/mg tissue wet weight) in the brain areas and intestine in pigeons at t = 3 hr of cisplatin administration (n = 6–8)

From: Anti-emetic mechanisms of zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates

Treatment NA DOPAC DA 5HIAA HVA 5HT
Area postrema
Saline 0.610 ± 0.014 0.382 ± 0.111 0.590 ± 0.146 0.158 ± 0.036 0.913 ± 0.095 0.062 ± 0.034
Cisplatin 1.879 ± 1.622 0.312 ± 0.183 0.080 ± 0.030 0.316 ± 0.101# 0.555 ± 0.188 0.282 ± 0.120
MCP 30 mg 0.023 ± 0.005 0.017 ± 0.006 0.025 ± 0.012 0.005 ± 0.001* 0.121 ± 0.063* 0.023 ± 0.001
ZO-ActFr 50 mg 0.605 ± 0.221 0.080 ± 0.027 1.147 ± 0.615 0.013 ± 0.001*** 0.171 ± 0.133 0.006 ± 0.002*
Brain stem
Saline 0.094 ± 0.022 0.060 ± 0.020 0.175 ± 0.078 0.060 ± 0.021 0.060 ± 0.016 0.010 ± 0.003
Cisplatin 0.094 ± 0.024 0.173 ± 0.136 0.030 ± 0.001 0.036 ± 0.004### 0.028 ± 0.003 0.131 ± 0.020###
MCP 30 mg 0.119 ± 0.033 0.027 ± 0.006 0.044 ± 0.012 0.007 ± 0.001*** 0.066 ± 0.031 0.019 ± 0.002
ZO-ActFr 50 mg 0.633 ± 0.050 0.015 ± 0.002 0.133 ± 0.077 0.018 ± 0.002*** 0.147 ± 0.054 0.037 ± 0.004***
Intestine
Saline 0.194 ± 0.059 0.067 ± 0.020 0.090 ± 0.064 0.076 ± 0.058 0.056 ± 0.025 0.049 ± 0.016
Cisplatin 0.222 ± 0.044 0.015 ± 0.003 0.022 ± 0.005 0.295 ± 0.024### 0.038 ± 0.004 0.665 ± 0.125###
MCP 30 mg 0.138 ± 0.039 0.054 ± 0.025 0.059 ± 0.018 0.097 ± 0.022 0.198 ± 0.102 0.062 ± 0.013
ZO-ActFr 50 mg 0.328 ± 0.036 0.088 ± 0.109 0.005 ± 0.055 0.030 ± 0.013*** 0.124 ± 0.066 0.049 ± 0.021***
  1. Values significantly different compared to cisplatin control are indicated as *p < 0.05, ***p < 0.001, while Values significantly different as compared to basal level are indicated as #p < 0.05, ###p < 0.001 (ANOVA followed by Tukey post hoc analysis).