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Table 1 Effect of ZO-ActFr or MCP on cisplatin induced R + V and jerking during a 24 h observation period

From: Anti-emetic mechanisms of zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates

Drug treatment Dose and route Pigeons n/ vomited R + V Mean ± sem Latency (min) Mean ± sem Jerks Mean ± sem Wt loss (%)Mean ± sem
Saline + Cisplatin 02 ml/kg i.m. + 07 mg/kg i.v. 6/6 43 ± 4.3 68 ± 3.7 407 ± 64 16.6 ± 1.8
MCP + Cisplatin 30 mg/kg i.m. + 07 mg/kg i.v. 8/8 22 ± 4.3* 230 ± 84** 447 ± 103 11.5 ± 1.5
ZO-ActFr + Cisplatin 25 mg/kg i.m. + 07 mg/kg i.v. 7/7 24 ± 4.1 124 ± 21 246 ± 92 8.1 ± 1.0*
50 mg/kg i.m. + 07 mg/kg i.v. 7/7 18 ± 4.2* 77 ± 15 376 ± 97 11.3 ± 2.3
100 mg/kg i.m. + 07 mg/kg i.v. 8/8 31 ± 5.6 85 ± 15 569 ± 125 9.1 ± 1.6
  1. *p < 0.05, **p < 0.01 (ANOVA followed by Tukey post hoc test).