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Table 4 Biochemical parameters of male and female rats administered with Derris reticulata extract for 42 days

From: Antioxidant, α-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: its antidiabetic potential

Parameters Control Treatment
250 mg/kg 500 mg/kg 1000 mg/kg 2000 mg/kg
Male      
Glucose (mg/dl) 125.8 ± 10.4 114.3 ± 10.7 135.8 ± 5.1 114.0 ± 2.0 118.5 ± 4.3
Total cholesterol (mg/dl) 61.50 ± 2.60 52.75 ± 3.50 61.50 ± 4.52 44.50 ± 2.84 50.75 ± 5.82
Triglyceride (mg/dl) 80.75 ± 18.44 85.50 ± 6.61 81.75 ± 13.83 76.75 ± 6.16 93.75 ± 23.02
Creatinine (mg/dl) 0.78 ± 0.09 0.65 ± 0.03 0.69 ± 0.04 0.68 ± 0.01 0.67 ± 0.04
AST (U/l) 96.25 ± 7.39 96.00 ± 6.49 99.00 ± 9.46 95.00 ± 10.98 98.00 ± 8.37
ALT (U/l) 32.75 ± 4.27 28.25 ± 3.64 33.25 ± 2.93 25.50 ± 2.72 29.25 ± 3.09
Female      
Glucose (mg/dl) 101.0 ± 8.2 91.00 ± 2.1 104.5 ± 7.0 101.8 ± 7.0 83.75 ± 4.4
Total cholesterol (mg/dl) 53.00 ± 2.80 45.50 ± 3.20 45.75 ± 4.64 44.25 ± 1.49 42.25 ± 5.47
Triglyceride (mg/dl) 40.50 ± 10.21 47.25 ± 3.50 52.25 ± 14.63 35.75 ± 2.87 47.75 ± 7.12
Creatinine (mg/dl) 0.74 ± 0.06 0.83 ± 0.06 0.73 ± 0.04 0.74 ± 0.07 0.76 ± 0.02
AST (U/l) 93.75 ± 6.21 86.00 ± 5.87 88.00 ± 7.36 75.00 ± 5.45 86.00 ± 4.06
ALT (U/l) 24.25 ± 2.50 35.25 ± 13.33 23.75 ± 1.55 19.25 ± 0.48 23.00 ± 1.47
  1. Values are expressed as mean ± S.E.M. (n = 4/group).
  2. There was no significant difference among control and treatment groups (p > 0.05).