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Table 3 Haematological parameters of male rats administered with Derris reticulata extract for 42 days

From: Antioxidant, α-glucosidase inhibitory activity and sub-chronic toxicity of Derris reticulata extract: its antidiabetic potential

Parameters

Control

Treatment

250 mg/kg

500 mg/kg

1000 mg/kg

2000 mg/kg

Male

     

RBC (×106/μl)

9.15 ± 0.21

9.55 ± 0.11

8.56 ± 0.24

8.82 ± 0.28

8.80 ± 0.16

HGB (g/dl)

17.75 ± 0.25

17.50 ± 0.29

16.50 ± 0.50

17.25 ± 0.63

16.75 ± 0.25

HCT (%)

52.50 ± 1.56

50.25 ± 0.63

47.00 ± 1.68

48.00 ± 2.12

47.00 ± 0.91

WBC (×103/μl)

1.48 ± 0.28

5.58 ± 1.84

4.50 ± 1.43

3.80 ± 0.38

2.15 ± 0.70

LYM (%)

83.50 ± 2.96

75.50 ± 5.72

85.00 ± 2.48

85.50 ± 1.66

82.50 ± 5.12

MON (%)

3.25 ± 2.02

3.25 ± 1.11

2.75 ± 1.44

2.75 ± 0.85

2.00 ± 1.00

EOS (%)

0.25 ± 0.25

0.50 ± 0.29

0.75 ± 0.25

0.50 ± 0.29

0.75 ± 0.75

BAS (%)

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

PLT (103/μl)

731.3 ± 45.3

863.0 ± 44.5

638.8 ± 35.7

667.8 ± 21.4

798.8 ± 43.5

MCV (fl)

57.10 ± 0.58

52.63 ± 0.37*

54.90 ± 0.38*

54.30 ± 0.86*

53.45 ± 0.43*

MCH (pg)

19.25 ± 0.24

18.35 ± 0.10*

19.40 ± 0.14

19.18 ± 0.18

19.03 ± 0.11

MCHC (g/dl)

33.65 ± 0.30

34.88 ± 0.17*

35.38 ± 0.29*

35.28 ± 0.26*

35.63 ± 0.36*

  1. Values are expressed as mean ± S.E.M. (n = 4/group).
  2. *p < 0.05 statistically significant difference from control.
  3. Note that all of the parameters in treated groups that were different compared to control are within the normal ranges.