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Table 2 Effect of Holothuria arenicola extract on serum cholestatic markers of BDL rats

From: Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats

Parameters Time period Groups % of improvement
Sham BDL HaE
ALP (IU/L) 7 149.49 ± 12.63a 218.29 ± 4.00b 208.51 ± 19.31b 6.5
14 148.55 ± 12.88a 250.80 ± 26.41b 247.14 ± 4.84b 2.46
28 149.75 ± 12.69a 247.18 ± 3.30b 153.70 ± 14.27a 62.40
Total bilirubin (mg/100 ml) 7 0.50 ± 0.08a 1.42 ± 0.67b 0.44 ± 0.8a 196
14 0.48 ± 0.08a 1.30 ± 0.38b 0.43 ± 1.72 a 181
28 0.47 ± 0.08a 1.41 ± 0.72b 0.53 ± 0.42a 206
Direct bilirubin (mg/100 ml) 7 0.19 ± 0.02a 1.18 ± 0.4b 1.02 ± 0.38a 84.21
14 0.20 ± 0.02a 1.45 ± 0.31b 1.10 ± 0.54a 175
28 0.25 ± 0.02a 1.99 ± 0.17b 1.42 ± 0.30a 228
Indirect bilirubin (mg/100 ml) 7 0.24 ± 0.02a 1.3 ± 0.31b 1.09 ± 0.24a 87.5
14 0.24 ± 0.02a 1.01 ± 0.46b 0.62 ± 0.76c 162.5
28 0.28 ± 0.2a 1.61 ± 0.56b 0.98 ± 0.76c 225
  1. Data are means ± SEM of six rats in each group.
  2. Unshared letters between groups are the significance values at p < 0.05.