Figure 5From: Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilageMolecular mechanism of Ecd chondroprotective effect. Both physical and chemical factors may induce cartilage degradation via IL-1β/ HIF-2α pathway; 20-Hydroxyecdysone (Ecd) does have chondroprotective effect and can inhibit IL-1β- induced cartilage catabolism via HIF-2α pathway.Back to article page