→ Variation of the primary outcome (averaged pain intensity) |
→ Frequency of pain attacks per day |
→ Pain intensity: |
▪ Pain at rest |
▪ Pain attack |
→ Time to symptom alleviation |
→ Analgesic demand |
→ Side effects of the therapy |
→ Standardised pain questionnaires |
▪ Neuropathic Pain questionnaire (NPI) |
▪ Quality of life (SF 36) |
▪ Pain Disability Index (PDI) |
▪ Pain description acc. to Geissner (SES) |
▪ Pain discomfort list acc. to van Zerssen |
→ Quantitative sensory testing (QST): |
▪ thermic sensation: |
▪ cold and warm detection threshold (CDT + WDT) |
▪ thermic difference threshold (TSL) |
▪ cold and heat pain threshold (CPT + HPT) |
▪ tactile detection threshold |
▪ mechanical pain threshold |
▪ mechanical pain intensity |
▪ mechanical allodynia |
▪ wind up phenomenon |
▪ vibration threshold |
▪ pressure pain threshold |
→ Change of rash before and after treatment |
→ Incidence of postherpetic neuralgia 6 month after treatment |
→ Credibility |
→ Cost effectiveness |
→ Side effects |