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Table 2 Proteins down regulated by F4 Fraction

From: Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells

Down regulated proteins Accesion Number
Translation  
Asparaginyl-tRNA synthetase NP_004530
BAT1 protein BAF31287
CGI-74 protein AAD34069
Dhx9 (DEAH) P-9, RNA Helicasa A (RHA)/DEAH (Asp-Glu-Ala-His) NP_001348
Eukariotic translation elongation factor 1 gamma AAH13918
Eukariotic translation elongation factor-2 (EF-2). NP_001952
Eukaryotic initiation factor 4A (eIF-4A) NP_001407
Heparin-binding protein HBp15 solo un articulo AAP97261
Heterogeneous nuclear ribonucleoprotein H1 NP_005511
Heterogeneous nuclear ribonucleoprotein U isoform a (scaffold attachment factor-A) NP_114032
Interleukin enhancer binding factor 3, 90 Kda EAW84137
Nucleolin NP_005372
Nucleosome assembly protein 1-like 1 NP_631946
Poly(rC)-binding protein 2 isoform b variant PCBP2 NP_114336
Small nuclear ribonucleoprotein Sm D1 CAE11897
Tryptophanyl-tRNA synthetase (IFP53) CAA44450
Tu-transcription elongation factor. ET-1 o EF-Tu NP_003312
Transcription processing  
CGI-74 AAD34069
DEAD (Asp-Glu-Ala-His) box polypeptide 21 NP_004719
DEAD (Asp-Glu-Ala-His) box polypeptide 9 NP_001348
Ribosomal Proteins  
Ribosomal protein L4 NP_000959
Ribosomal protein L5 EAW73088
Ribosomal protein L7a EAW88064
Ribosomal protein L8 NP_000964
Ribosomal protein L9 NP_000652
Ribosomal protein L10 NP_006004
Ribosomal protein L10a NP_009035
Ribosomal protein L11 NP_000966
Ribosomal protein L12 BAD92708
Ribosomal protein L13 NP_150254
Ribosomal protein L13a AAQ13495
Ribosomal protein L14 NP_004964
Ribosomal protein L18 NP_000970
Ribosomal protein L18a XP_943475
Ribosomal protein L19 EAW60568
Ribosomal protein L23 NP_000969
Ribosomal protein L26 NP_001087230
Ribosomal protein L27 NP_000979
Ribosomal protein L27a NP_001083056
Ribosomal protein L28 NP_000982
Ribosomal protein L31 NP_000984
Ribosomal protein L32 NP_000985
Ribosomal protein L36 NP_378669
Ribosomal protein L37a NP_000989
Ribosomal protein S2 NP_002943
Ribosomal protein S4 EAW71815
Ribosomal protein S5 BAD93040
Ribosomal protein S6 NP_001001
Ribosomal protein S8 EAX07023
Ribosomal protein S11 NP_001006
Ribosomal protein S12 EAW54624
Ribosomal protein S13 NP_001008
Ribosomal protein S15a EAW50259
Ribosomal protein S18 NP_001087248
Ribosomal protein S19 NP_001013
Ribosomal protein S24 EAW54624
Ribosomal protein S25 NP_001019
Ribosomal protein S27 EAW91426
Ribosomal protein P0 variant BAD96291
Replication  
CSE1 chromosome segregation 1-like protein NP_001307
ErbB3 (HER3) binding protein 1 NP_006182
Nucleolin NP_005372
Protein Kinase, DNA-activated, catalytic polypeptide isoform 1 NP_008835
Degradation Proteins  
26S proteasome subunit p45 BAA07919
Flap structure-specific endonuclease 1 NP_004102
Fumarate hydratase, isoform CRA_b EAW70091
Histone cluster 1, H1d NP_005311
HMG-1 BAA09924
Hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 NP_004484
Mitochondrial acetoacetyl-CoA thiolase BAA01387
PSMC3 protein AAI07805
Transporters  
Mitochondrial trifunctional protein, alpha subunit precursor NP_000173
Prohibitin 2 (Phb2) NP_009204
Solute carrier family 25 (SLC25A5 protein) AAH68199
Cytoskeleton  
Actin, gamma 1 propeptide NP_001605
Adenylyl cyclase-associated protein NP_006358
Chaperonin containing TCP-1 (subunit 6 A and 7) NP_006420
Dynein light chain 1 NP_003737
F-actin capping protein alpha 1 NP_006126
Kinesin NP_004512
Lamin A/C, isoform CRA_c AAH00511
Lamin B1 NP_005564
Miller-Dieker lissencephaly protein AAL34972
Myosin heavy polypeptide 9 NP_002464
Myosin, light polypeptide 6B, alkali, smooth muscle and non-muscle, isoform CRA_c EAW96898
Plectin NP_958782
t-complex polypeptide 1 (TCP-1) CAA37064
Tubulin alpha 6 NP_116093
Signal Transduction  
RAB5C, member RAS oncogene family isoform b NP_004574
Guanine nucleotide binding protein (G-protein) EAW53700
IQ Motif containing GTPase activating protein 1 BAA06123
Prohibitin (PHB) CAG46507
RAN member RAS oncogene familly EAW98517
Chaperones  
HSP70-prot 8 NP_006588
HSP60 ABB01006
Tumor rejection antigen (gp96) or Heat schock protein 90 Kda beta CAI64497
Heat shock protein 90 kDa alpha (HSP90) NP_005339
Metabolism  
ACLY variant protein BAE06117
ATP synthase, H+ transporting, mitochondrial F1 complex, beta subunit precursor NP_001677
Dihydropyrimidinase-like 2 variant BAD92432
Enolase 1, variant BAD96912
Fatty acid synthase AAA41145
Glucose phosphate isomerase NP_000166
Glucosidase II CAA04006
Glyceraldehyde-3-phosphate dehydrogenase NP_002037
Lactate dehydrogenase A NP_005557
Peroxiredoxin 6 NP_004896
Phosphoglicerate kinase (PGK) NP_000282
Phosphoglycerate dehydrogenase NP_006614
Prostaglandin E synthase 3 (cytosolic) AAH03005
Pyruvate Kinase, muscle isoform CRA_c AAH12811
Tumoral Antigen  
Melanoma-associated antigen 4 (MAGE 4 antigen) P43358
Calcium binding proteins  
Annexin 5 NP_001145
Annexine A2 isoform 1 NP_001002858
  1. Proteins from A375 human cells treated with F4 or ethanol (0.2%) as negative control were digested, and the extracted peptides injected onto a 1100 Series HPLC-Chip Cube MS interface, and Agilent 6300 Series Ion Trap Chip-LC-MS/MS system (Agilent Technologies). Data are the proteins down regulated by F4 fraction treatment as judged by mass spectrometry.