Table 2 PK parameter estimates of IDV before and after co-administration with AG (1 gram every 8 hours), n = 13
| Â | IDV alone (Day 7) GM (95%CI) | IDV + AG (Day 22) GM (95%CI) | Day 7/Day 22 Geometric Mean Ratio (90% CI) |
|---|---|---|---|
C max (ng/mL) | 5623 (4027–7853) | 5633 (4908–6464) | 1.00 (0.77–1.29) |
C min (ng/mL) | 61.97 (42.72–89.88) | 62.78 (39.72–99.24) | 1.00 (0.77–1.29) |
t max (hours) | 0.98 (0.7189–1.3403) | 0.74 (0.5527–0.9870) | 0.75 (0.53–1.06) |
AUC 0–8 (ng·h/dL) | 12171 (8628–17168) | 10700 (8515–13649) | 0.89 (0.72–1.08) |