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Table 3 The effect of PK, Omez, and indomethacin as such and in combination with PK or Omez on the gastric secretion of pylorous ligated mice.a

From: Healing Potential of Picrorhiza kurroa (Scrofulariaceae) rhizomes against indomethacin-induced gastric ulceration: a mechanistic exploration.

Mice

Gastric juice (ml) (6 h)

pH

Acid output (μEq/6 h)

Experimental control

0.85 ± 0.1

3.56

183.6 ± 6.8

Treated with PK

0.7 ± 0.1

3.41

179.2 ± 4.6

Treated with indomethacin

1.6 ± 0.2b

2.3

256.6 ± 10.2a

Treated with PK + indomethacin

1.3 ± 0.1c

3.46

206.2 ± 5.9c

Treated with Omez

0.75 ± 0.09

3.36

186.5 ± 6.8c

Treated with Omez + indomethacin

0.9 ± 0.12d

3.25

173.6 ± 6.4c

  1. aUntreated and treated mice were subjected to pylorous ligation. The treatment groups were orally administered PK (20 mg/kg/day × 3 days), Omez (3 mg/kg/day × 3 days), indomethacin (18 mg/kg × 1 d) as such or along with PK and Omez at the designated doses. The values are mean ± SEM (n = 5). a P < 0.05, b P < 0.01 compared to the experimental control mice c P < 0.05, d P < 0.01 compared to the indomethacin-treated mice