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Table 8 Effect of extract on phagocytic activity of peritoneal macrophages

From: Acanthus montanus: An experimental evaluation of the antimicrobial, anti-inflammatory and immunological properties of a traditional remedy for furuncles

Extract

Dose (mg/kg)

Macrophage Count

Macrophage phagocytic activity

   

Free Cells

Proportion of free cells (%)

Cells with ingested C. albicans

Proportion of cells with ingested C. albicans (%)

Control

-

6.33 ± 0.88

5.3 ± 0.88

84.13

1.00 ± 0.0

15.87

AE

200

7.97 ± 0.38

6.1 ± 0.29

76.53

1.87 ± 0.13

23.46

 

400

9.53 ± 1.92

7.3 ± 1.57

76.84

2.20 ± 0.42

23.16

 

800

14.20 ± 2.62*

9.3 ± 0.75*

65.49

6.10 ± 3.02*

42.96

Metronidazole

300

9.75 ± 0.9

4.25 ± 0.14

43.59

5.50 ± 0.43*

56.41

  1. AE = Aqueous Extract; Values of macrophage count shown are Mean ± SEM calculated per high power field (n = 3 determinations); Values in parenthesis represent percentage increase in number of macrophages calculated relative to control; Proportion (%) of free cells (cells without C. albicans) and cells with ingested C. albicans were calculated relative to the total number of macrophages; * P < 0.05 compared to control (ANOVA; LSD post hoc).