Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Table 3 Effect of naloxone on the anticonvulsant activity of Pasipay in PTZ-induced convulsion in mice

Treatment (dose)	Onset (sec)	Duration (sec)	Mortality protection (%)
Normal saline (10 ml/kg)	51.83 ± 64	12 ± 1.80	0
Naloxone (5 mg/kg)	10.66 ± 0.66	49.6 ± 4.34	0
Pasipay (0.4 mg/kg)	600 ± 0***	0 ± 0***	100
Pasipay+ Naloxone	125.4 ± 2.87***	8.81 ± 2.64	40

Normal saline and Pasipay were administered (i.p.) 30 min before the injection of PTZ (90 mg/kg, i.p.); Naloxone was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *** p < 0.001, compared to saline group, Tukey-Kramer test.

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