Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies

Table 6 Experiment B: Carageenan edema and oral administration

Drug	Paw volume increase over time (ml ± SD) and effect (% of negative control)
	1 hr		3 hr		5 hr		7hr
Saline	0.39 ± 0.17		0.77 ± 0.16		0.63 ± 0.18		0.54 ± 0.16
Apis D4	0.37 ± 0.11	-7	0.81 ± 0.11	+6	0.70 ± 0.20	+12	0.60 ± 0.15	+11
Apis D30	0.43 ± 0.11	+8	0.82 ± 0.11	+7	0.73 ± 0.17	+16	0.59 ± 0.13	+10
Lachesis D6	0.40 ± 0.12	+1	0.79 ± 0.19	+3	0.71 ± 0.18	+14	0.58 ± 0.17	+7
Lachesis D30	0.40 ± 0.17	+2	0.79 ± 0.19	+3	0.75 ± 0.19	+19	0.59 ± 0.21	+10
Phosphorus D6	0.40 ± 0.15	+1	0.80 ± 0.18	+4	0.70 ± 0.16	+11	0.59 ± 0.20	+10
Phosphorus D30	0.41 ± 0.16	+3	0.85 ± 0.23	+11	0.72 ± 0.21	+14	0.59 ± 0.18	+10
Indomethacin i.m.	0.30 ± 0.14	-24	0.48 ± 0.15	-38	0.52 ± 0.10	-18	0.43 ± 0.10	-20

ANOVA results for measurements from 1 to 7 hrs since edema induction. Treatment: F(7,14) = 4.23, p = 0.0105; Time: (F(3,6) = 26.91, p = 0.0007; Treatment × time (different profiles over time between treatments): F(21,42) = 2.07, p = 0.1010; Replication × time (different profiles over time between replications): F(6,45) = 8.61, p < 0.0001; Replication × treatment × time (different profiles over time between replications and treatments): F(42,315) = 1.65, p = 0.0110.
Bold characters denote significant comparisons (by Student t test) vs. Saline group corresponding for time since edema induction.

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