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Table 4 Mean VAS that assessed pain and stiffness, Lequesne's functional index and time for climbing up 10 steps in intent-to-treat patients (n = 100/group).

From: Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892]

Variable Treatment Group Week 0 Week 1 Week 2 Week 3 Week 4 % improvementa
VAS that assessed pain (mm)
   Walking pain DJW 64.53 (24.92) 47.58* (25.33) 37.72* (25.00) 28.00* (23.25) 18.06* (20.76) 72.01
  Diclofenac 64.78 (25.14) 44.08* (23.43) 34.99* (22.07) 24.21* (21.00) 14.31* (16.10) 77.91
   Standing pain DJW 52.42 (25.87) 39.81* (26.09) 31.61* (24.89) 24.29* (22.98) 16.89* (20.59) 67.78
  Diclofenac 53.52 (24.69) 37.60* (24.06) 28.19* (22.40) 21.12* (21.16) 12.86* (16.69) 75.97
   Pain during climbing up and down stairs DJW 63.08 (20.87) 46.31* (26.56) 36.40* (25.67) 28.16* (24.03) 18.41* (21.50) 70.81
  Diclofenac 62.69 (23.21) 43.90* (22.29) 32.61* (22.42) 24.59* (21.79) 15.83* (19.65) 74.75
   Night pain DJW 50.15 (26.74) 33.44* (27.27) 23.56* (22.79) 15.68* (18.14) 9.27* (15.04) 81.52
  Diclofenac 48.45 (28.18) 28.93* (22.82) 20.87* (19.56) 15.02* (17.87) 8.65* (14.68) 82.15
   Resting pain DJW 38.48 (22.09) 27.25* (21.99) 19.96* (19.98) 12.64* (15.56) 7.42* (13.09) 80.72
  Diclofenac 37.12 (26.08) 22.84* (20.62) 16.26* (18.19) 11.30* (16.40) 6.58* (13.96) 82.27
   Total painb DJW 268.65 (88.87) 194.38* (105.06) 149.24* (103.19) 108.76* (92.54) 70.04* (83.94) 73.93
  Diclofenac 266.55 (89.33) 177.34* (85.49) 132.91* (84.50) 96.21* (81.94) 58.23* (70.43) 78.15
   Pain during the most painful knee movement DJW 82.25 (16.15) 63.31* (26.35) 49.77* (28.70) 37.69* (28.45) 26.81* (27.70) 67.40
  Diclofenac 81.17 (16.56) 56.79* (24.87) 43.64* (27.30) 33.10* (27.17) 22.84* (25.85) 71.86
VAS that assessed stiffness (mm)
   Morning stiffness DJW 53.53 (27.38) 36.61* (25.56) 28.04* (23.86) 19.66* (20.53) 12.34* (17.69) 76.95
  Diclofenac 58.32 (26.40) 38.73* (23.87) 28.52* (21.93) 20.19* (20.23) 12.90* (17.34) 77.88
   Stiffness after rest DJW 68.52 (22.76) 51.69* (24.93) 39.40* (25.31) 29.05* (24.60) 19.62* (23.06) 71.37
  Diclofenac 70.45 (22.32) 49.71* (24.68) 39.54* (24.97) 28.23* (24.17) 18.90* (20.60) 73.17
   Total stiffnessc DJW 122.05 (41.98) 88.30* (45.93) 67.44* (46.25) 48.71* (42.82) 31.96* (38.84) 73.81
  Diclofenac 128.76 (42.34) 88.44* (43.84) 68.06* (43.03) 48.42* (41.97) 31.80* (36.07) 75.30
Lequesne's functional index (score) DJW 14.20 (3.13) 11.60* (4.11) 11.05* (4.04) 9.93* (4.40) 8.92* (4.60) 37.18
  Diclofenac 14.80 (2.61) 10.89* (3.38) 10.65* (3.55) 9.59* (3.52) 8.64* (3.83) 41.62
Time for climbing up 10 steps (s) DJW 13.44 (4.85) 11.65* (4.75) 11.42* (4.67) 10.94* (4.73) 10.50* (4.38) 21.88
  Diclofenac 13.32 (5.10) 11.26* (5.12) 11.14* (5.72) 10.61* (5.51) 10.18* (4.46) 23.57
  1. Data represent mean (SD). aCalculated by (meanweek0-meanweek4) × 100/meanweek0. bSummation of VAS that assessed walking pain, standing pain, pain during climbing up and down stairs, night pain and resting pain. cSummation of VAS that assessed morning stiffness and stiffness after rest. *p < 0.05 versus base-line value.