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Table 1 Percentage blood glucose reduction produced by C. roseus after oral administration in normal rabbits.

From: The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits

Group

(n = 5)

Dose

Initial Blood glucose (mg/dl)

Percent blood glucose reduction

   

4

6

8

10

12

16

18

20

24 (h)

Control

---

105.6

-3.1 ± 5.3

-2.4 ± 6.4

-0.4 ± 6.2

-3.6 ± 5.0

-6.9 ± 6.3

-4.5 ± 4.2

-0.4 ± 9.9

5.9 ± 1.5

-1.5 ± 4.6

C. roseus

0.50 ml/kg

99.2

11.5 ± 0.7*

16.7 ± 1.2*

15.3 ± 3.1

12.6 ± 2.4*

4.9 ± 8.0

4.6 ± 6.6

8.1 ± 2.1

8.9 ± 1.9

1.0 ± 4.4

C. roseus

0.75 ml/kg

101.4

13.9 ± 5.1*

17.1 ± 1.9*

19.5 ± 3.4*

19.7 ± 5.7*

22.8 ± 3.1**

27.0 ± 0.7***

28.6 ± 0.4*

14.7 ± 6.2

4.3 ± 7.1

C. roseus

1.0 ml/kg

108.5

14.1 ± 3.3*

17.5 ± 3.2*

19.2 ± 2.6*

20.8 ± 6.1*

24.4 ± 4.4**

29.6 ± 4.2***

30.7 ± 5.2*

31.9 ± 5.3**

30.0 ± 1.4***

Glibenclamide

40 μg/kg

104.2

25.5 ± 4.1**

29.7 ± 4.9**

31.9 ± 4.8**

29.8 ± 5.2**

28.3 ± 4.7**

23.1 ± 3.6**

21.9 ± 3.6

19.8 ± 5.4

17.3 ± 4.7

  1. Values are mean percent blood glucose reduction (± S.E.M.) of five animals. Significant difference from control at corresponding intervals: *p < 0.05, **p < 0.01, ***p < 0.001