Figure 6From: Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor The role of berberine in TLR4/MD-2 signaling. The recognition of LPS is facilitated by LBP and CD14, and is mediated by TLR4/MD-2 receptor complex. Upon the recognition, LPS/TLR4 signaling can be separated into MyD88-dependent and MyD88- independent pathways, which mediate the activation of proinflammatory cytokine and Type I interferon genes.Back to article page