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Table 3 Human BACE-1 inhibitory in vitro activity of four curcuminoids, two phytochemicals and BACE-1 inhibitor IV

From: Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models

Compound

IC50, μM (95% CL)

Slope ± SE

Curcumin

340 (296–391)

0.7 ± 0.03

Demethoxycurcumin

217 (197–240)

1.0 ± 0.05

Bisdemethoxycurcumin

17 (14–20)

1.9 ± 0.21

Tetrahydrocurcumin

> 2000

 

(−)-Epigallocatechin gallate

82.01(72.59–92.66)

0.9 ± 0.04

BACE-1 inhibitor IV

0.085 (0.075–0.095)

1.2 ± 0.07

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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